2. Epigenetics
  3. Histone Methyltransferase
  4. IHMT-EZH2-426

IHMT-EZH2-426 (compound 38) is a potent and covalent EZH2 degrader with IC50s of 1.3 nM, 1.2 nM, and 1.7-3.5 nM against EZH2 wild-type, EZH2-A687V, and EZH2-Y641F/Y641N/Y641S, respectively. IHMT-EZH2-426 exhibits potent antiproliferation effects against both B-cell lymphoma and triple negative breast cancer (TNBC) cell lines by reducing the levels of H3K27me3 and EZH2.

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IHMT-EZH2-426 Chemical Structure

IHMT-EZH2-426 Chemical Structure

CAS No. : 3018914-66-1

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IHMT-EZH2-426 Related Antibodies

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Description

IHMT-EZH2-426 (compound 38) is a potent and covalent EZH2 degrader with IC50s of 1.3 nM, 1.2 nM, and 1.7-3.5 nM against EZH2 wild-type, EZH2-A687V, and EZH2-Y641F/Y641N/Y641S, respectively. IHMT-EZH2-426 exhibits potent antiproliferation effects against both B-cell lymphoma and triple negative breast cancer (TNBC) cell lines by reducing the levels of H3K27me3 and EZH2[1].

IC50 & Target[1]

EZH2 WT

1.3 nM (IC50)

EZH2-A687V

1.2 nM (IC50)

Y641F/Y641N/Y641S

1.7-3.5 nM (IC50)

Molecular Weight

578.70

Formula

C31H35FN4O4S
CAS No.
SMILES

O=C(C1=CC(C(C=CC(F)=C2)=C2NC(C=C)=O)=CC(N(C3CCOCC3)C)=C1C)NCC4=C(SC)C=C(C)NC4=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IHMT-EZH2-426 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IHMT-EZH2-4263018914-66-1Histone MethyltransferaseY641FY641NY641Sand A687Vcovalent EZH2 degraderantiproliferation effectsH3K27me3Inhibitorinhibitorinhibit

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