SP27
Based on 1 Customer Validation
SP27 is a PROTAC that can selective degrades PLK4, with a DC50 of 19.5 nM. SP27 can be used for the research of breast cancer.
(Pink: PLK4 ligand (HY-128493); Blue: Cereblon ligand (HY-14658); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 3034805-75-6
- Formula: C40H40F2N12O5
- Molecular Weight:806.82
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.073 μM
Compound: SP27
|
Antiproliferative activity against human MCF7 cells incubated for 5 days by CCK-8 assay
Antiproliferative activity against human MCF7 cells incubated for 5 days by CCK-8 assay
|
[PMID: 37279162] |
Chemical Information
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CAS No. 3034805-75-6
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Appearance Solid
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Molecular Weight 806.82
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Formula C40H40F2N12O5
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Color Light yellow to yellow
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SMILES
FC1=CC=C(C(F)=C1)CNC2=NC3=C(C=NN3C4CCN(CC4)C(C5CCN(CC5)C6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)C(NC9=NNC(C)=C9)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (123.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2394 mL | 6.1972 mL | 12.3943 mL | 30.9858 mL |
| 5 mM | 0.2479 mL | 1.2394 mL | 2.4789 mL | 6.1972 mL | |
| 10 mM | 0.1239 mL | 0.6197 mL | 1.2394 mL | 3.0986 mL | |
| 15 mM | 0.0826 mL | 0.4131 mL | 0.8263 mL | 2.0657 mL | |
| 20 mM | 0.0620 mL | 0.3099 mL | 0.6197 mL | 1.5493 mL | |
| 25 mM | 0.0496 mL | 0.2479 mL | 0.4958 mL | 1.2394 mL | |
| 30 mM | 0.0413 mL | 0.2066 mL | 0.4131 mL | 1.0329 mL | |
| 40 mM | 0.0310 mL | 0.1549 mL | 0.3099 mL | 0.7746 mL | |
| 50 mM | 0.0248 mL | 0.1239 mL | 0.2479 mL | 0.6197 mL | |
| 60 mM | 0.0207 mL | 0.1033 mL | 0.2066 mL | 0.5164 mL | |
| 80 mM | 0.0155 mL | 0.0775 mL | 0.1549 mL | 0.3873 mL | |
| 100 mM | 0.0124 mL | 0.0620 mL | 0.1239 mL | 0.3099 mL |
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