3034805-75-6
Chemical Structure
SP27
- CAS No.: 3034805-75-6
- Formula:C40H40F2N12O5
- Molecular Weight:806.82
InChIKey: NTSTTXFDEIQUET-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(F)=C1)CNC2=NC3=C(C=NN3C4CCN(CC4)C(C5CCN(CC5)C6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)C(NC9=NNC(C)=C9)=N2
Biological Activity: SP27 is a PROTAC PLK4 degrader with an IC50 of 8.4 nM and a DC50 of 19.5 nM against PLK4. SP27 induces PLK4 degradation via the CRBN-dependent ubiquitin-proteasome pathway, inhibits PLK4 downstream signal transduction, and suppresses the growth of TRIM37-amplified breast cancer cells. SP27 is applicable for breast cancer-related research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SP27 | 98.87% | SP27 is a PROTAC PLK4 degrader with an IC50 of 8.4 nM and a DC50 of 19.5 nM against PLK4. SP27 induces PLK4 degradation via the CRBN-dependent ubiquitin-proteasome pathway, inhibits PLK4 downstream signal transduction, and suppresses the growth of TRIM37-amplified breast cancer cells. SP27 is applicable for breast cancer-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
