3034805-75-6
3034805-75-6
Chemical Structure
SP27
- CAS 番号: 3034805-75-6
- Formula:C40H40F2N12O5
- Molecular Weight:806.82
InChIKey: NTSTTXFDEIQUET-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(F)=C1)CNC2=NC3=C(C=NN3C4CCN(CC4)C(C5CCN(CC5)C6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)C(NC9=NNC(C)=C9)=N2
Biological Activity: SP27 is a PROTAC PLK4 degrader with an IC50 of 8.4 nM and a DC50 of 19.5 nM against PLK4. SP27 induces PLK4 degradation via the CRBN-dependent ubiquitin-proteasome pathway, inhibits PLK4 downstream signal transduction, and suppresses the growth of TRIM37-amplified breast cancer cells. SP27 is applicable for breast cancer-related research[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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SP27 | 98.87% | SP27 is a PROTAC PLK4 degrader with an IC50 of 8.4 nM and a DC50 of 19.5 nM against PLK4. SP27 induces PLK4 degradation via the CRBN-dependent ubiquitin-proteasome pathway, inhibits PLK4 downstream signal transduction, and suppresses the growth of TRIM37-amplified breast cancer cells. SP27 is applicable for breast cancer-related research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.62
HY-170405YB-3-17 -
Similarity Score 0.62
HY-162280PROTAC BTK Degrader-9 -
Similarity Score 0.61
HY-160142UBX-382 -
Similarity Score 0.59
HY-149391PROTAC BTK Degrader-6 -
Similarity Score 0.59
HY-161708PROTAC FLT3/CDKs degrader-1 -
Similarity Score 0.58
HY-149843LC-MB12 -
Similarity Score 0.58
HY-168518PROTAC CDK9 degrader-9 -
Similarity Score 0.58
HY-181050DFCI-002-06 -
Similarity Score 0.58
HY-153536PROTAC BTK Degrader-3 -
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