1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. HDAC8-IN-1

HDAC8-IN-1 

Cat. No.: HY-111342 Purity: 99.59%
Handling Instructions

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.

For research use only. We do not sell to patients.

HDAC8-IN-1 Chemical Structure

HDAC8-IN-1 Chemical Structure

CAS No. : 1417997-93-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.

IC50 & Target

HDAC8

27.2 nM (IC50)

In Vitro

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].

Molecular Weight

345.39

Formula

C₂₂H₁₉NO₃

CAS No.

1417997-93-3

SMILES

O=C(NO)/C=C/C1=CC=C(OC)C=C1C2=CC=C(C3=CC=CC=C3)C=C2.[E]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (434.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8953 mL 14.4764 mL 28.9528 mL
5 mM 0.5791 mL 2.8953 mL 5.7906 mL
10 mM 0.2895 mL 1.4476 mL 2.8953 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product name:
HDAC8-IN-1
Cat. No.:
HY-111342
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