Obestatin Antibody (YA1227)
(Synonyms: GHRL; MTLRP; UNQ524/PRO1066; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46; Ghrelin-27Ghrelin-28 (Ghrelin); Obestatin)Obestatin Antibody (YA1227) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Obestatin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.306.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-1:2000 |
Product Details
Obestatin Antibody (YA1227) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Obestatin.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 13 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 13 kDa
A synthesized peptide derived from human Obestatin
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.306.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Obestatin is a Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation; May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility[1].
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy -
Isoforms & Post-Translational Modification
Q9UBU3 has 6 isomers: Q9UBU3-1: 12911 Da (predicted); Q9UBU3-2: 12783 Da (predicted); Q9UBU3-3: 11784 Da (predicted); Q9UBU3-4: 11656 Da (predicted); Q9UBU3-5: 7460 Da (predicted); Q9UBU3-6: 9972 Da (predicted).
O-octanoylated by GOAT/MBOAT4 (PubMed:18443287). O-octanoylation or O-decanoylation is essential for ghrelin activity (PubMed:10604470). The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26 (PubMed:10604470). A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (PubMed:10604470). Also O-acetylated and O-butyrylated on Ser-26 to minor levels (PubMed:18443287);Amidation of Leu-98 is essential for obestatin activity -
SwissProt ID
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Synonyms
GHRL; MTLRP; UNQ524/PRO1066; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46; Ghrelin-27Ghrelin-28 (Ghrelin); Obestatin
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Research Field
Neuroscience
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