1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. EGFR mutant-IN-1

EGFR mutant-IN-1 

Cat. No.: HY-125841
Handling Instructions

EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor with an IC50 of 27.5 nM, while being a significantly less potent for EGFRWT (IC50 >1.0 μM).

For research use only. We do not sell to patients.

EGFR mutant-IN-1 Chemical Structure

EGFR mutant-IN-1 Chemical Structure

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Description

EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor with an IC50 of 27.5 nM, while being a significantly less potent for EGFRWT (IC50 >1.0 μM)[1].

IC50 & Target

IC50: 27.5 nM (EGFRL858R/T790M/C797S) and >1.0 μM (EGFRWT)[1]

Molecular Weight

632.17

Formula

C₃₄H₃₉ClFN₇O₂

SMILES

O=C1C(C2=CC=CC(F)=C2Cl)=C(C)C3=CN=C(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)N=C3N1[[email protected]]6CN(C(CC)=O)CCC6

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
EGFR mutant-IN-1
Cat. No.:
HY-125841
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