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Cat. No.: HY-N10082

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Trigoxyphin A

Trigoxyphin A is a oxygenated daphnane-type diterpenoids. Trigoxyphin A exhibites strong cytotoxic activity against HL60 and A549 with IC₅₀s of 0.27 and 7.5 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1236874-00-2
Formula: C₃₄H₃₄O₉
Molecular Weight:586.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Trigoxyphin A Chemical Structure

CAS No.: 1236874-00-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Trigoxyphin A is a oxygenated daphnane-type diterpenoids. Trigoxyphin A exhibites strong cytotoxic activity against HL60 and A549 with IC₅₀s of 0.27 and 7.5 μM, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 8	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay	[PMID: 21192108]
A549	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 20593838]
Bel-7402	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay	[PMID: 20593838]
HL-60	IC₅₀	>10 μM Compound: 8	Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 21192108]
HL-60	IC₅₀	0.27 μM Compound: 1	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 20593838]
MCF7	IC₅₀	>10 μM Compound: 8	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay	[PMID: 21192108]

Chemical Information

CAS No. 1236874-00-2
Molecular Weight 586.63
Formula C₃₄H₃₄O₉
SMILES

C[C@H]1[C@]23[C@]([C@H]4[C@](O4)([C@H]([C@]5([C@@]3([H])C=C(C5=O)C)O)O)C)([H])[C@]6([H])[C@]([C@H]1OC(C7=CC=CC=C7)=O)(O[C@](O6)(C8=CC=CC=C8)O2)C(C)=C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin BD, et al. Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides. J Nat Prod. 2010 Jul 23;73(7):1301-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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