Trigonosins A-F, daphnane diterpenoids from Trigonostemon thyrsoideum

  • J Nat Prod. 2011 Mar 25;74(3):464-9. doi: 10.1021/np1006444.
Shi-Fei Li  1 ,  Ying-Tong Di ,  Shun-Lin Li ,  Yu Zhang ,  Fu-Mei Yang ,  Qian-Yun Sun ,  James Mpetga Simo ,  Hong-Ping He ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 21192108 DOI: 10.1021/np1006444
Abstract

Phytochemical study of the roots of Trigonostemon thyrsoideum led to the isolation of four new oxygenated daphnane-type Diterpenoids, trigonosins A-D (1-4), and two new modified daphnanes, trigonosins E and F (5 and 6). The structures and relative configurations were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. All compounds isolated were evaluated for their cytotoxicity against HL-60, A549, and MCF-7 human Cancer cell lines.