Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides

  • J Nat Prod. 2010 Jul 23;73(7):1301-5. doi: 10.1021/np100320h.
Bing-Dong Lin  1 ,  Mei-Ling Han ,  Yin-Chun Ji ,  Hua-Dong Chen ,  Sheng-Ping Yang ,  Sheng Zhang ,  Mei-Yu Geng ,  Jian-Min Yue
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.
PMID: 20593838 DOI: 10.1021/np100320h
Abstract

Six new oxygenated daphnane-type Diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.

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