1. Immunology/Inflammation
  2. COX
  3. S-(+)-Ketoprofen

S-(+)-Ketoprofen (Synonyms: (S)-Ketoprofen; Dexketoprofen)

Cat. No.: HY-B2137 Purity: 99.95%
Handling Instructions

S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.

For research use only. We do not sell to patients.

S-(+)-Ketoprofen Chemical Structure

S-(+)-Ketoprofen Chemical Structure

CAS No. : 22161-81-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

Other Forms of S-(+)-Ketoprofen:

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  • Technical Information

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Description

S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.

IC50 & Target[1]

COX-1

13 μM (IC50)

COX-2

370 μM (IC50)

In Vitro

S-(+)-Ketoprofen (Compound 1) is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (491.58 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9327 mL 19.6634 mL 39.3267 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL
10 mM 0.3933 mL 1.9663 mL 3.9327 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

254.28

Formula

C₁₆H₁₄O₃

CAS No.

22161-81-5

SMILES

O=C(C1=CC=CC([[email protected]@H](C(O)=O)C)=C1)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.95%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
S-(+)-Ketoprofen
Cat. No.:
HY-B2137
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S-(+)-Ketoprofen

Cat. No.: HY-B2137