2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. VEGFR-2-IN-11

VEGFR-2-IN-11 (Compound 8h) is a potent VEGFR-2 inhibitor with an IC50 of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cell apoptosis.

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VEGFR-2-IN-11 Chemical Structure

VEGFR-2-IN-11 Chemical Structure

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VEGFR-2-IN-11 Related Antibodies

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Description

VEGFR-2-IN-11 (Compound 8h) is a potent VEGFR-2 inhibitor with an IC50 of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cell apoptosis[1].

IC50 & Target

VEGFR-2

60.27 nM (IC50)

In Vitro

VEGFR-2-IN-11 (Compound 8h) (0-100 µM) shows antiproliferation activities against tumor cells and induces a low toxic effect in normal cells[1].
VEGFR-2-IN-11 (4.92 µM, 24h) arrests the cell cycle on MCF-7 at a G1/S phase and induces MCF-7 cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-11 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT-116, HEPG-2, and MCF-7
Concentration: 0-100 µM
Incubation Time:
Result: Showed antiproliferation activities with IC50 values of 8.62 ± 0.7, 10.18 ± 0.8, and 4.92 ± 0.2 µM against HCT-116, HEPG-2, and MCF-7 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7
Concentration: 4.92 µM
Incubation Time: 24 h
Result: Resulted in a significant increase in the ratio of MCF-7 cells in the G0/G1 phase from 45.81 % (untreated cells) to 49.18 % and the S phase from 39.14% (untreated cells) to 43.22% with a concomitant decrease in the number of cells in G2/M phase by 7.6% compared to untreated control (15.05%).

Apoptosis Analysis[1]

Cell Line: MCF-7
Concentration: 4.92 µM
Incubation Time: 24 h
Result: Induced the early apoptosis in MCF-7 (3.46%) 6.4 folds over the untreated cells (0.54%). Enhanced the late apoptotic induction by 20.72% compared to untreated control (0.18%). Induced total apoptosis with 36.24%.

Cell Cytotoxicity Assay[1]

Cell Line: WI-38
Concentration: 0-100 µM
Incubation Time:
Result: Induced a low toxic effect with an IC50 value of 44.45 ± 3.2 µM against WI-38 cells.
Molecular Weight

552.49

Formula

C29H22BrN5S
SMILES

S=C(NC1=CC=C(C=C1)NC2=NC(/C=C/C3=CC=C(C=C3)Br)=NC4=CC=CC=C42)NC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-11VEGFRApoptosisVascular endothelial growth factor receptorantitumorHCT-116HEPG-2MCF-7Inhibitorinhibitorinhibit

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