VEGFR-2-IN-11
VEGFR-2-IN-11 (Compound 8h) is a potent VEGFR-2 inhibitor with an IC50 of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cell apoptosis.
For research use only. We do not sell to patients.
- Formula: C29H22BrN5S
- Molecular Weight:552.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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VEGFR-2 60.27 nM (IC50) |
VEGFR-2-IN-11 (Compound 8h) (0-100 µM) shows antiproliferation activities against tumor cells and induces a low toxic effect in normal cells[1].
VEGFR-2-IN-11 (4.92 µM, 24h) arrests the cell cycle on MCF-7 at a G1/S phase and induces MCF-7 cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, HEPG-2, and MCF-7
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Concentration:0-100 µM
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Incubation Time:
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Result:Showed antiproliferation activities with IC50 values of 8.62 ± 0.7, 10.18 ± 0.8, and 4.92 ± 0.2 µM against HCT-116, HEPG-2, and MCF-7 cells, respectively.
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Cell Line:MCF-7
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Concentration:4.92 µM
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Incubation Time:24 h
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Result:Resulted in a significant increase in the ratio of MCF-7 cells in the G0/G1 phase from 45.81 % (untreated cells) to 49.18 % and the S phase from 39.14% (untreated cells) to 43.22% with a concomitant decrease in the number of cells in G2/M phase by 7.6% compared to untreated control (15.05%).
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Cell Line:MCF-7
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Concentration:4.92 µM
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Incubation Time:24 h
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Result:Induced the early apoptosis in MCF-7 (3.46%) 6.4 folds over the untreated cells (0.54%). Enhanced the late apoptotic induction by 20.72% compared to untreated control (0.18%). Induced total apoptosis with 36.24%.
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Cell Line:WI-38
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Concentration:0-100 µM
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Incubation Time:
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Result:Induced a low toxic effect with an IC50 value of 44.45 ± 3.2 µM against WI-38 cells.
Chemical Information
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Molecular Weight 552.49
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Formula C29H22BrN5S
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SMILES
S=C(NC1=CC=C(C=C1)NC2=NC(/C=C/C3=CC=C(C=C3)Br)=NC4=CC=CC=C42)NC5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-11 Related Classifications
HY-145856 Related Classifications
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