RNase A, Bovine pancreas
Based on 6 publication(s) in Google Scholar
RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability.
For research use only. We do not sell to patients.
- CAS No.: 9001-99-4
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) RNase A, Bovine pancreas
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Biological Activity
RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
3.1.27.5
≥60 Kunitz U/mg soild
One unit is defined as the amount of enzyme that an increase in absorbance of 0.001 at 260 nm in 1 min at 50°C and pH 5.0, using 1.5 mL yeast RNA at 0.15 mg/mL as substrate.
Chemical Information
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CAS No. 9001-99-4
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Appearance Solid
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Color White to off-white
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SMILES
[RNase A, Bovine pancreas]
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Synonyms
Ribonuclease A; EC 4.6.1.18; RNase A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Nov 26;16(1):10575. PMID: 41298461 -
Nat Commun
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation. [Abstract]2025 Feb 25;16(1):1774. PMID: 40000627 -
Cell Death Dis
Hypoxia-induced exosomal LUCAT1 promotes osimertinib resistance in lung adenocarcinoma by stabilizing c-MET. [Abstract]2025 Oct 27;16(1):763. PMID: 41145422 -
Proc Natl Acad Sci U S A
Methionine-specific nonreversible bioconjugation: Advancing precision protein modification. [Abstract]2026 Feb 17;123(7):e2519038123. PMID: 41665996 -
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Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Dang W, et al. RNase A activity analysis and imaging using label-free DNA-templated silver nanoclusters. Talanta. 2020 Mar 1;209:120512. [Content Brief]
[2]. Nogués MV, et al. Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites. Biochim Biophys Acta. 1995 Nov 15;1253(1):16-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RNase A, Bovine pancreas Related Classifications
HY-129046 Related Classifications
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