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  4. Monoclonal Antibodies Recombinant Antibodies
  5. SAFB1 Antibody (YA1043)

SAFB1 Antibody (YA1043)

Cat. No.: HY-P81306A
User Guide for Antibodies Technical Support

SAFB1 Antibody (YA1043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAFB1.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

SAFB1 Antibody (YA1043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAFB1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 103 kDa;
Observed band size: 150 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human SAFB
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
IHC-F
IHC-F: Immunohistochemistry-Frozen
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity)
Subcellular Localization：Nucleus
Expression：
Tissue_specificity:It is widely distributed. It is highly expressed in the central nervous system and lowly expressed in the liver. It is also expressed in various breast cancer cell lines.
Isoforms & Post-Translational Modification：Q15424 has 4 isomers: Q15424-1: 102642 Da (predicted); Q15424-2: 95181 Da (predicted); Q15424-3: 102855 Da (predicted); Q15424-4: 102768 Da (predicted).
Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity
Subunit：Monomer and homodimer (PubMed:12660241). Forms heterodimers with SAFB2 (PubMed:12660241). Interacts with KHDRBS3 (By similarity). Interacts with CLK2 (By similarity). Interacts with POLR2A, SRSF1/ASF, SRSF9/SRp30c and SFSF10/TRA2B (PubMed:9671816). Interacts with isoform 1 and isoform 2 of SRPK1 and inhibits its activity (PubMed:19674106). Interacts with RBMX (By similarity). Interacts with FUS (PubMed:27731383). Interacts with ZBED4 (PubMed:22693546)
Database

Entrez Gene: 6294 Human ; 224902 Mouse ;

SwissProt: Q15424 Human ; Q80YR5 Mouse ; O88453 Rat

OMIM: 602895 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein
Documentation
User Guide for Antibodies (1077 KB)

SAFB1 Antibody (YA1043) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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