SAFB - scaffold attachment factor B Gene

Also Known as HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6294

About SAFB

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,623,083-5,668,478 (from NCBI)

This gene has 14 transcripts (splice variants), 235 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.9), testis (RPKM 26.5) and 25 other tissues.

Summary

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an Estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

SAFB Products (6)

mRNA Protein Name
NM_001201338.2 NP_001188267.1 scaffold attachment factor B1 isoform 1
NM_001201339.2 NP_001188268.1 scaffold attachment factor B1 isoform 2
NM_001201340.2 NP_001188269.1 scaffold attachment factor B1 isoform 4
NM_001320571.2 NP_001307500.1 scaffold attachment factor B1 isoform 5
NM_001320572.2 NP_001307501.1 scaffold attachment factor B1 isoform 6
NM_002967.4 NP_002958.2 scaffold attachment factor B1 isoform 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12660241 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22693546 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAFB Protein Structure

SAP

SAP: SAP domain (31 - 65)

(409 - 477)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 915 a.a.
Protein Preferred Names Protein Names

scaffold attachment factor B1

  • HSP27 ERE-TATA-binding protein

SAFB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SAFB Q15424 SAFB2 Homo sapiens Q14151
Anti Tag CoIP
12660241
Intra
SAFB Q15424 SAFB2 Homo sapiens Q14151
Y2H
12660241
Intra
SAFB Q15424 TP53 Homo sapiens P04637
Anti Bait CoIP
21130767
Intra
SAFB Q15424 TP53 Homo sapiens P04637
IF
21130767
Intra
SAFB Q15424 SRPK1 Homo sapiens Q96SB4-2
Anti Tag CoIP
19674106
Intra
SAFB Q15424 SRPK1 Homo sapiens Q96SB4-2
Pull Down
19674106
Cross: Cross-species interaction Intra: Intraspecies interaction

SAFB Antibodies

Cat. No. Product Name Application Reactivity
HY-P81306 SAFB1 Antibody (YA1042) WB, ICC/IF, ChIP Human
HY-P81306A SAFB1 Antibody (YA1043) WB, IHC-F, IHC-P, ICC/IF Human, Mouse
HY-P81306AA SAFB1 Antibody (YA1043)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse
HY-P85538 SAFB1 Antibody (YA5230) WB, ICC/IF Human

Related Diseases

Diseases Alias
Denys-Drash Syndrome

  • Drash Syndrome

  • DDS

  • Nephropathy, Wilms Tumor, And Genital Anomalies

  • Wilms Tumor And Pseudohermaphroditism

  • Wilms Tumor And Pseudo- Or True Hermaphroditism

  • Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor

  • Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor

  • Wilms Tumor-Dsd Syndrome

  • Wilms Tumor-Disorder Of Sex Development Syndrome
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181794 Z19024498 Activator / Unkown
HY-RS12413 SAFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12414 SAFB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SAFB VGNC VGNC:76964
Felis catus SAFB VGNC VGNC:64854
Canis familiaris SAFB VGNC VGNC:45844
Rattus norvegicus SAFB RGD RGD:620613
Mus musculus SAFB MGD MGI:2146974
Others SAFB NCBI