SAFB2 - scaffold attachment factor B2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9667

About SAFB2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,586,999-5,622,776 (from NCBI)

This gene has 11 transcripts (splice variants), 99 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 19.8), spleen (RPKM 18.1) and 25 other tissues.

Summary

The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of Estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, Apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]

SAFB2 Products (1)

mRNA Protein Name
NM_014649.3 NP_055464.1 scaffold attachment factor B2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
19674106 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12660241 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAFB2 Protein Structure

SAP

SAP: SAP domain (30 - 63)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (409 - 478)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 953 a.a.
Protein Preferred Names Protein Names

scaffold attachment factor B2

SAFB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SAFB2 Q14151 SORBS3 Homo sapiens O60504-2
Anti Bait CoIP
12660241
Intra
SAFB2 Q14151 SORBS3 Homo sapiens O60504-2
Confocal
12660241
Intra
SAFB2 Q14151 SAFB Homo sapiens Q15424
Anti Tag CoIP
12660241
Intra
SAFB2 Q14151 TRIP6 Homo sapiens Q15654
Anti Tag CoIP
33961781
Intra
SAFB2 Q14151 SAFB2 Homo sapiens Q14151
Pull Down
19674106
Intra
SAFB2 Q14151 ESR1 Homo sapiens P03372
Pull Down
12660241
Intra
SAFB2 Q14151 DHPS Homo sapiens P49366
Anti Tag CoIP
33961781
Intra
SAFB2 Q14151 DHPS Homo sapiens P49366
Anti Tag CoIP
28514442
Intra
SAFB2 Q14151 SAFB2 Homo sapiens Q14151
Anti Tag CoIP
19674106
Intra
SAFB2 Q14151 TRIP6 Homo sapiens Q15654
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12414 SAFB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SAFB2 VGNC VGNC:77080
Felis catus SAFB2 VGNC VGNC:64855
Rattus norvegicus SAFB2 RGD RGD:1588577
Bos taurus SAFB2 VGNC VGNC:34262
Canis familiaris SAFB2 VGNC VGNC:45845
Mus musculus SAFB2 MGD MGI:2146808
Others SAFB2 NCBI