1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. VU 0365114

VU 0365114 

Cat. No.: HY-107651 Purity: 99.41%
Handling Instructions

VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.

For research use only. We do not sell to patients.

VU 0365114 Chemical Structure

VU 0365114 Chemical Structure

CAS No. : 1208222-39-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 690 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

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Description

VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.

IC50 & Target

EC50: 2.7 μM (mAChR M5)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 77.5 mg/mL (195.04 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5167 mL 12.5834 mL 25.1667 mL
5 mM 0.5033 mL 2.5167 mL 5.0333 mL
10 mM 0.2517 mL 1.2583 mL 2.5167 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.58 mg/mL (6.49 mM); Clear solution; Need warming

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (6.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

397.35

Formula

C₂₂H₁₄F₃NO₃

CAS No.

1208222-39-2

SMILES

O=C1N(C2=CC=C(OC(F)(F)F)C=C2C1=O)CC3=CC=C(C4=CC=CC=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
VU 0365114
Cat. No.:
HY-107651
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VU 0365114

Cat. No.: HY-107651