1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Leucylarginylproline

Leucylarginylproline 

Cat. No.: HY-P0143
Handling Instructions

Leucylarginylproline is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.27μM.

For research use only. We do not sell to patients.

Leucylarginylproline Chemical Structure

Leucylarginylproline Chemical Structure

CAS No. : 133943-59-6

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Description

Leucylarginylproline is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.27μM.

IC50 & Target

IC50: 0.27μM (ACE)[1]

In Vitro

Intravenous injection of Leucylarginylproline (30mg/kg) causes a decrease in the blood pressure. The maximum mean blood pressure reduction (about 15 mmHg) occurrs about 2 min after the injection[1]. Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration[2].

Molecular Weight

384.47

Formula

C₁₇H₃₂N₆O₄

CAS No.

133943-59-6

Sequence

Leu-Arg-Pro

Sequence Shortening

LRP

SMILES

O=C(O)[[email protected]]1N(C([[email protected]](CCCNC(N)=N)NC([[email protected]](CC(C)C)N)=O)=O)CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Kinase Assay
[1]

Hip-His-Leu (5mM) and an ACE inhibitor (Leucylarginylproline) are dissolved in a 100 mM sodium borate buffer (pH 8.3) containing 300 mM NaCl, and incubated for 30 min with 8 milliunits of ACE at 37°C. The ACE inhibitor concentration required to inhibit 50% of the ACE activity under the above conditions is defined as IC50[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Rats: Leucylarginylproline is dissolved in 1.0 mM normal saline. After being warmed up, rats are orally administered (0.18 mmol/kg bw) with peptides or normal saline (control). Tail systolic blood pressures are measured at 2-h intervals (0, 2, 4, 6, 8, 10, and 12 h) after the administration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

LeucylarginylprolineAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Leucylarginylproline
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