1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Trandolapril

Trandolapril (Synonyms: RU44570)

Cat. No.: HY-B0592 Purity: 98.01%
Handling Instructions

Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI).

For research use only. We do not sell to patients.

Trandolapril Chemical Structure

Trandolapril Chemical Structure

CAS No. : 87679-37-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 98 In-stock
Estimated Time of Arrival: December 31
50 mg USD 395 In-stock
Estimated Time of Arrival: December 31
100 mg USD 718 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Trandolapril:

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Description

Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI)[1].

Clinical Trial
Molecular Weight

430.54

Formula

C₂₄H₃₄N₂O₅

CAS No.

87679-37-6

SMILES

O=C([[email protected]]1N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)[[email protected]@]3([H])CCCC[[email protected]]3([H])C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3227 mL 11.6133 mL 23.2266 mL
5 mM 0.4645 mL 2.3227 mL 4.6453 mL
10 mM 0.2323 mL 1.1613 mL 2.3227 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

TrandolaprilRU44570RU 44570RU-44570Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Trandolapril
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