1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Trandolapril

Trandolapril (Synonyms: RU44570)

Cat. No.: HY-B0592 Purity: 99.67%
Handling Instructions

Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI).

For research use only. We do not sell to patients.

Trandolapril Chemical Structure

Trandolapril Chemical Structure

CAS No. : 87679-37-6

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Solution
10 mM * 1 mL in DMSO USD 108 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
10 mg USD 98 In-stock
Estimated Time of Arrival: December 31
50 mg USD 395 In-stock
Estimated Time of Arrival: December 31
100 mg USD 718 In-stock
Estimated Time of Arrival: December 31
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Description

Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI)[1].

IC50 & Target

Target: Angiotensin-converting Enzyme (ACE)[1]

In Vivo

Trandolapril (3 mg/kg/day; p.o.; 7 d) reduces renal fibrosis in obstructive nephropathy in mice, by inhibiting renal interstitial matrix expression and myofibroblast activation, decreasing renal proinflammatory cytokine RANTES and TNF-α level[2].
Trandolapril (0.3 mg/kg/day; p.o.; 4 weeks) improves arterial mechanics in rats, prevents arterial hypertrophy, collagen and cellular fibronectin accumulation[3].
randolapril (0.3 mg/kg/day; p.o.; 4 months) exhibits a chronic anti-hypertension effects in rats, results in blood pressure decreasing[3].
Trandolapril (0.25 mg/kg; p.o.; twice a day; 4 months) inhibits Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UUD (unilateral ureteral obstruction) model in Male CD-1 mice (18-22 g)[2]
Dosage: 3 mg/kg
Administration: Oral gavage; daily, for 7 days
Result: Resulted in renal interstitial matrix expression (including fibronectin, type I, and type III collagen) decreasing, and inhibited myofibroblast activation by surprising a-smooth muscle actin (a-SMA) expression, decreased the RANTES (regulated on activation, normal T cell expressed and secreted) and TNF-α level.
Animal Model: SHR model (spontaneously hypertensive rats, 4-week-old)[3]
Dosage: 0.3 mg/kg
Administration: Oral gavage; daily for 4 weeks
Result: Reduced collagen content in the aortic media and increased ariterial distensibility up to about 80%.
Animal Model: Watanabe heritable hyperlipidemic rabbit (3 months old)[4]
Dosage: 0.25 mg/kg
Administration: Oral gavage; twice a day; 9 months
Result: Decreased in atherosclerotic involvement of the intimal surface, and also decreased cholesterol content in descending thoracic aorta.
Clinical Trial
Molecular Weight

430.54

Formula

C24H34N2O5

CAS No.
SMILES

O=C([[email protected]]1N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)[[email protected]@]3([H])CCCC[[email protected]]3([H])C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3227 mL 11.6133 mL 23.2266 mL
5 mM 0.4645 mL 2.3227 mL 4.6453 mL
10 mM 0.2323 mL 1.1613 mL 2.3227 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.98%

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Trandolapril
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