NY0116
NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
For research use only. We do not sell to patients.
- CAS No.: 1003000-59-6
- Formula: C22H23N3O
- Molecular Weight:345.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NY0116 has potent dose-dependent inhibition of cAMP (EC50 of 1.69 nM) in HEK293 cells stably expressing hNMUR2. NY0116 also stimulates calcium signaling in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male diet induced obese (DIO) C57BL/6J mice age 18 weeks and 8 age[1]
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Dosage:3, 10, 30 mg/kg
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Administration:Subcutaneous injection; for 14 days
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Result:Significantly decreased bodyweight compared to vehicle, whereas mice were maintained on a high-fat diet.
Chemical Information
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CAS No. 1003000-59-6
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Molecular Weight 345.44
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Formula C22H23N3O
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SMILES
NC(NCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NY0116 Related Classifications
HY-124681 Related Classifications
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