1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. Ubiquitination-IN-1

Ubiquitination-IN-1 

Cat. No.: HY-135199
Handling Instructions

Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 can be used to treat disease by blocking the degradation of tumor suppressors.

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Ubiquitination-IN-1 Chemical Structure

Ubiquitination-IN-1 Chemical Structure

CAS No. : 1819330-15-8

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Description

Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 can be used to treat disease by blocking the degradation of tumor suppressors[1].

In Vitro

Ubiquitination-IN-1 inhibits A549 and HT1080 cells with IC50s of 0.91 and 0.4 μM, respectively[1].

Molecular Weight

429.41

Formula

C₂₁H₁₄F₃N₃O₂S

CAS No.

1819330-15-8

SMILES

O=S(C1=CC=CC(C(F)(F)F)=C1)(NC2=C3N=CC=CC3=C(C4=CC=CN=C4)C=C2)=O

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Keywords:

Ubiquitination-IN-1E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseubiquitinationCkslSkp2protein-proteininteractiondegradationtumorsuppressorsInhibitorinhibitorinhibit

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Ubiquitination-IN-1
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