DNA relaxation-IN-1
Based on 1 Customer Validation
DNA relaxation-IN-1 (Compound 27) is a DNA ligase 1 DNA Lig1) inhibitor. DNA relaxation-IN-1 inhibits DNA ligation and disrupts the DNA relaxing activity of DNA Lig1. DNA relaxation-IN-1 induces Apoptosis. DNA relaxation-IN-1, in combination with Topotecan (HY-13768), exhibits synergistic antiproliferative effects against colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 98.61%
- CAS No.: 2190506-29-5
- Formula: C30H27N3O2S
- Molecular Weight:493.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Colorectal Cancer Compound Library
HY-L103
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Cell Death Library
HY-L162
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MCE Bioactive Compound Library
HY-L001V
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
All DNA/RNA Synthesis Isoforms
More
Biological Activity
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DNA Ligase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
4.656 μM
Compound: 27
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Antiproliferative activity against human DLD1 cells after 48 hrs by MTT assay
Antiproliferative activity against human DLD1 cells after 48 hrs by MTT assay
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[PMID: 29146133] |
| HEK293 | IC50 |
12.4 μM
Compound: 27
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Cytotoxicity against HEK293 cells after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells after 48 hrs by MTT assay
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[PMID: 29146133] |
| HeLa | IC50 |
6.398 μM
Compound: 27
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Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
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[PMID: 29146133] |
| HepG2 | IC50 |
6.457 μM
Compound: 27
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Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 29146133] |
| MDA-MB-231 | IC50 |
6.09 μM
Compound: 27
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
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[PMID: 29146133] |
DNA relaxation-IN-1 (10 µM) can effectively inhibit the DNA relaxation activity of hLig I[1].
DNA relaxation-IN-1 (1.25-2.5 µM) combined with Topotecan exhibits synergistic cell-killing effects in DLD-1 cells[1].
DNA relaxation-IN-1 (2.5 µM; 48 h) induces apoptosis in DLD-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2190506-29-5
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Appearance Solid
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Molecular Weight 493.62
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Formula C30H27N3O2S
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CS1)/C=C/C2=CC(C(C3=C(C)NC4=C3C=CC=C4)C(C#N)=C(N)O5)=C5C(C(C)(C)C)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (202.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0258 mL | 10.1292 mL | 20.2585 mL | 50.6462 mL |
| 5 mM | 0.4052 mL | 2.0258 mL | 4.0517 mL | 10.1292 mL | |
| 10 mM | 0.2026 mL | 1.0129 mL | 2.0258 mL | 5.0646 mL | |
| 15 mM | 0.1351 mL | 0.6753 mL | 1.3506 mL | 3.3764 mL | |
| 20 mM | 0.1013 mL | 0.5065 mL | 1.0129 mL | 2.5323 mL | |
| 25 mM | 0.0810 mL | 0.4052 mL | 0.8103 mL | 2.0258 mL | |
| 30 mM | 0.0675 mL | 0.3376 mL | 0.6753 mL | 1.6882 mL | |
| 40 mM | 0.0506 mL | 0.2532 mL | 0.5065 mL | 1.2662 mL | |
| 50 mM | 0.0405 mL | 0.2026 mL | 0.4052 mL | 1.0129 mL | |
| 60 mM | 0.0338 mL | 0.1688 mL | 0.3376 mL | 0.8441 mL | |
| 80 mM | 0.0253 mL | 0.1266 mL | 0.2532 mL | 0.6331 mL | |
| 100 mM | 0.0203 mL | 0.1013 mL | 0.2026 mL | 0.5065 mL |
DNA relaxation-IN-1 Related Classifications
HY-161152 Related Classifications
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