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  3. YIL781 hydrochloride

YIL781 hydrochloride 

Cat. No.: HY-13964A
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YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL-781 hydrochloride inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively.

For research use only. We do not sell to patients.

YIL781 hydrochloride Chemical Structure

YIL781 hydrochloride Chemical Structure

CAS No. : 1640226-17-0

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Description

YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL-781 hydrochloride inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively[1][2][3][4].

In Vitro

YIL-781 (10-300 nM) induces a concentration-dependent parallel rightward shift of the ghrelin CRC with a slight but statistically significant depression of the maximal response at 100 and 300 nM, reaching a similar agonist maximal response of approximately 90%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YIL781 (0.1 to 5 μg/5 μl) attenuates ghrelin-induced up-regulation of the blood glucose level. The i.t. treatment with YIL781 alone does not affect the blood glucose level (F = 0.8160; P = 0.5095)[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Conscious mice[4].
Dosage: 0.1 to 5 μg/5 μl.
Administration: Intrathecal (i.t.) injection.
Result: Attenuated ghrelin-induced up-regulation of the blood glucose level (F = 0.7506; P = 0.5729) (YIL781 5 g + ghrelin 5 g −9.1% at 30 min; −14.9% at 60 min).
The i.t. treatment with YIL781 alone did not affect the blood glucose level (F = 0.8160; P = 0.5095).
Molecular Weight

445.96

Formula

C₂₄H₂₉ClFN₃O₂

CAS No.

1640226-17-0

SMILES

O=C1N(C[[email protected]@H]2CN(C(C)C)CCC2)C(C)=NC3=C1C=C(OC4=CC=C(F)C=C4)C=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

YIL781YIL 781YIL-781GHSRGrowth hormone secretagogue receptorInhibitorinhibitorinhibit

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Product Name:
YIL781 hydrochloride
Cat. No.:
HY-13964A
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