BET-IN-7
BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis.
For research use only. We do not sell to patients.
- CAS No.: 303985-05-9
- Formula: C18H12ClN3OS
- Molecular Weight:353.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
2854 nM
Compound: 1
|
Inhibition of 11beta-HSD1 in mouse 3T3L1 cells
Inhibition of 11beta-HSD1 in mouse 3T3L1 cells
|
[PMID: 21983444] |
| HEK293 | IC50 |
1102 nM
Compound: 1
|
Inhibition of 11beta-HSD1 in human HEK cells
Inhibition of 11beta-HSD1 in human HEK cells
|
[PMID: 21983444] |
| HEK293 | IC50 |
27 nM
Compound: 1
|
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader
|
[PMID: 21983444] |
Chemical Information
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CAS No. 303985-05-9
-
Molecular Weight 353.83
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Formula C18H12ClN3OS
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SMILES
N#CC1=C(N=C(NC1=O)SCC2=CC=CC=C2Cl)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)