BET-IN-7
BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis.
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- CAS No.: 303985-05-9
- 화학식: C18H12ClN3OS
- 분자량:353.83
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
2854 nM
Compound: 1
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Inhibition of 11beta-HSD1 in mouse 3T3L1 cells
Inhibition of 11beta-HSD1 in mouse 3T3L1 cells
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[PMID: 21983444] |
| HEK293 | IC50 |
1102 nM
Compound: 1
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Inhibition of 11beta-HSD1 in human HEK cells
Inhibition of 11beta-HSD1 in human HEK cells
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[PMID: 21983444] |
| HEK293 | IC50 |
27 nM
Compound: 1
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Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader
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[PMID: 21983444] |
Chemical Information
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CAS No. 303985-05-9
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분자량 353.83
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화학식 C18H12ClN3OS
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SMILES
N#CC1=C(N=C(NC1=O)SCC2=CC=CC=C2Cl)C3=CC=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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LPS-Induced Endotoxemia/Systemic Inflammation
Lipopolysaccharide (LPS)-induced endotoxemia is a widely used in vivo model of acute systemic inflammation in which LPS, a Gram-negative bacterial endotoxin, activates innate immune signaling primarily through TLR4, leading to rapid and transient induction of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β in circulation and tissues. This cytokine surge is commonly used as a measurable readout of systemic inflammatory activation and immune dysregulation, and is typically assessed within hours after intraperitoneal LPS administration in mouse models of endotoxemia. The model captures key features of systemic inflammatory response syndrome, including cytokine release, immune cell activation, and downstream tissue responses, and has been used to evaluate anti-inflammatory interventions such as cytokine modulation, lipid mediators, and immune cell-targeting therapies.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BET-IN-7 Related Classifications
HY-146291 Related Classifications
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