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Cat. No.: HY-155654

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SARS-CoV-2 Mpro-IN-10

SARS-CoV-2 Mpro-IN-10 (27h) is a potent M^pro inhibitor with IC₅₀ value and EC₅₀ values of 10.9 nM and 43.6 nM, respectively. SARS-CoV-2 Mpro-IN-10 can be used for the research of SARS-CoV-2 virus.

For research use only. We do not sell to patients.

CAS No.: 2982834-87-5
Formula: C₂₈H₃₀F₄N₄O₄
Molecular Weight:562.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SARS-CoV-2 Mpro-IN-10 Chemical Structure

CAS No.: 2982834-87-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BEAS-2B	CC₅₀	>100 μM Compound: 27h	Cytotoxicity against human BEAS-2B cells Cytotoxicity against human BEAS-2B cells	[PMID: 37517202]
Vero	CC₅₀	>100 μM Compound: 27h	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 37517202]

Chemical Information

CAS No. 2982834-87-5
Molecular Weight 562.56
Formula C₂₈H₃₀F₄N₄O₄
SMILES

O=C(N[C@H](CC1=CC=CC=C1)C(C(NCC2=NC=CC=C2)=O)=O)[C@@H]3N(CC(F)(C3)F)C(C4CCC(F)(CC4)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang C, et al. Discovery and structure-activity relationship studies of novel α-ketoamide derivatives targeting the SARS-CoV-2 main protease. Eur J Med Chem. 2023 Nov 5;259:115657. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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