1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Tubulin inhibitor 13

Tubulin inhibitor 13 

Cat. No.: HY-143251
Handling Instructions

Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity.

For research use only. We do not sell to patients.

Tubulin inhibitor 13 Chemical Structure

Tubulin inhibitor 13 Chemical Structure

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Description

Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity[1].

In Vitro

Tubulin inhibitor 13 (E27) (0-100 μM, 72 h) exhibits antitumor activity with the IC50 values of 9.32 μM, 10.36μM and 7.81 μM against HepG2, A549 and HCT116, respectively, and shows cytotoxic effect on 293 T (human embryonic kidney cell) with an IC50 value of 49.30 μM[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) causes destruction, fragmentation and disintegration of microtubules, and significantly reduces cell migration in a dose-dependent manner in A549 cells[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) induces apoptosis in a dose-dependent manner and blocks the cell cycle in the G2/M phase in A549 cells[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) promotes the expression of pro-apoptotic markers such as BAX, cleaved caspase-3 and cleaved caspase-9 and decreases the expression of the anti-apoptotic protein Bcl-2 in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 5 and 10 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis by 42.6% and 54.1% at a concentration of 5 μM and 10 μM, respectively.
Showed G2/M phase cells of 31.38% and 37.10% at 5 μM and 10 μM, respectively, compared to 25.08% G2/M phase cells in the control group.
Molecular Weight

427.45

Formula

C25H21N3O4

SMILES

COC1=CC=C2N=C(C=C(C2=C1)C(N(CC3=NC=CC=C3)C)=O)C4=CC=C5OCOC5=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
Tubulin inhibitor 13
Cat. No.:
HY-143251
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