Tubulin inhibitor 13
Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2883436-66-4
- Formula: C25H21N3O4
- Molecular Weight:427.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Tubulin inhibitor 13 (E27) (0-100 μM, 72 h) exhibits antitumor activity with the IC50 values of 9.32 μM, 10.36μM and 7.81 μM against HepG2, A549 and HCT116, respectively, and shows cytotoxic effect on 293 T (human embryonic kidney cell) with an IC50 value of 49.30 μM[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) causes destruction, fragmentation and disintegration of microtubules, and significantly reduces cell migration in a dose-dependent manner in A549 cells[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) induces apoptosis in a dose-dependent manner and blocks the cell cycle in the G2/M phase in A549 cells[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) promotes the expression of pro-apoptotic markers such as BAX, cleaved caspase-3 and cleaved caspase-9 and decreases the expression of the anti-apoptotic protein Bcl-2 in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A549 cells
-
Concentration:5 and 10 μM
-
Incubation Time:24 hours
-
Result:Induced cell apoptosis by 42.6% and 54.1% at a concentration of 5 μM and 10 μM, respectively.
Showed G2/M phase cells of 31.38% and 37.10% at 5 μM and 10 μM, respectively, compared to 25.08% G2/M phase cells in the control group.
Chemical Information
-
CAS No. 2883436-66-4
-
Molecular Weight 427.45
-
Formula C25H21N3O4
-
SMILES
COC1=CC=C2N=C(C=C(C2=C1)C(N(CC3=NC=CC=C3)C)=O)C4=CC=C5OCOC5=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin inhibitor 13 Related Classifications
HY-143251 Related Classifications
Powered by Bioz