2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-2

CDK7-IN-2 

Cat. No.: HY-143587 Purity: 98.93%
COA Handling Instructions

CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1).

For research use only. We do not sell to patients.

CDK7-IN-2 Chemical Structure

CDK7-IN-2 Chemical Structure

CAS No. : 2326428-19-5

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Based on 1 publication(s) in Google Scholar

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Description

CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1)[1].

Molecular Weight

497.63

Appearance

Solid

Formula

C26H39N7O3
CAS No.
SMILES

O=C(N1CCC(NC2=CC(C)=NC3=C(C(C)C)C=NN23)CC1)O[[email protected]@H]4CN(C(/C=C/CN(C)C)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (200.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0095 mL 10.0476 mL 20.0953 mL
5 mM 0.4019 mL 2.0095 mL 4.0191 mL
10 mM 0.2010 mL 1.0048 mL 2.0095 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.02 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.93%

COA (248 KB) HNMR (308 KB) LCMS (270 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CDK7-IN-22326428-19-5CDKCyclin dependent kinasecell cycletranscriptional activityRNAPIIcancerInhibitorinhibitorinhibit

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