2. Neuronal Signaling
  3. Sigma Receptor
  4. AD186

AD186 is a potent and selective S1R agonist with Kis of 2.7, 27 nM for S1R and S2R, respectively. AD186 fully reverses the antiallodynic effect of BD-1063 (HY-18101A).

For research use only. We do not sell to patients.

AD186 Chemical Structure

AD186 Chemical Structure

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AD186 Related Antibodies

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Description

AD186 is a potent and selective S1R agonist with Kis of 2.7, 27 nM for S1R and S2R, respectively. AD186 fully reverses the antiallodynic effect of BD-1063 (HY-18101A)[1].

IC50 & Target[1]

Sigma 1 Receptor

2.7 nM (Ki)

Sigma 2 Receptor

27 nM (Ki)

In Vivo

AD186 (compound 4b) (2.5-10 mg/kg; s.c.) fully reverses the antiallodynic effect of BD-1063 (HY-18101A) in capsaicin-induced mechanical hypersensitivity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

320.47

Formula

C22H28N2
SMILES

N1(CCC2=CC=CC=C2)CC3(CCN(CC4=CC=CC=C4)CC3)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AD186 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD186AD 186AD-186Sigma ReceptorInhibitorinhibitorinhibit

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HY-149853
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