Dovitinib lactate hydrate

Dovitinib lactate hydrate purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2023 Apr;299(4):104595 [Abstract]

Customer Validation
Gcn2 KO HEK293 cells were transfected with empty vector (−), WT, K619A, T899A, or M2 Gcn2. Cells were treated with vehicle, 50 nM Gcn2iB, 1 μM neratinib, 2 μM dovitinib, or 2 μM dabrafenib for 6 h and then Atf4-Luc activity was measured and presented normalized to vehicle-treated cells with empty vector.

Dovitinib lactate hydrate purchased from MedChemExpress. Usage Cited in: NPJ Precis Oncol. 2021 Jul 16;5(1):66. [Abstract]

Customer Validation
3T3 cells expressing either the FGFR2 variant or KRAS G12V were incubated with a specified concentration of inhibitor for 5 days. Cell viability was measured using the PrestoBlue cell viability assay and plotted against an untreated control group.

Dovitinib lactate hydrate purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2020 May 7:8:287. [Abstract]

Customer Validation
Determination in L3.6 cells of FGF2-induced FGFR phosphorylation by Western blot in the presence of Dovitinib. FGFR1 and alpha-Tubulin are used as loading controls.

Dovitinib lactate hydrate purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]

Customer Validation
BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.