Dovitinib lactate hydrate
Based on 11 publication(s) in Google Scholar
Dovitinib lactate hydrate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.
For research use only. We do not sell to patients.
- CAS No.: 915769-50-5
- Formula: C24H29FN6O5
- Molecular Weight:500.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dovitinib lactate hydrate
More- Nat Commun. 2025 Jul 24;16(1):6777. [Abstract]
- Acta Pharm Sin B. 2026 Feb 10.
- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]
- NPJ Precis Oncol. 2021 Jul 16;5(1):66. [Abstract]
- Front Cell Dev Biol. 2020 May 7:8:287. [Abstract]
- J Biol Chem. 2023 Apr;299(4):104595 [Abstract]
- BMJ Open Ophthalmol. 2026 Jan 12;11(1):e002307. [Abstract]
- University of Düsseldorf. 2024.
- bioRxiv. 2024 June 09.
- Biochemistry for Health, NOVA University of Lisbon. 2019 Jul.
Customer Validation & Images
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WB
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WB
All VEGFR Isoforms
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Biological Activity
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FLT3 1 nM (IC50) |
c-Kit 2 nM (IC50) |
FGFR1 8 nM (IC50) |
FGFR3 9 nM (IC50) |
VEGFR1 1 nM (IC50) |
VEGFR3 8 nM (IC50) |
VEGFR2 13 nM (IC50) |
PDGFRα 27 nM (IC50) |
PDGFRβ 210 nM (IC50) |
Dovitinib potently inhibits the FGF-stimulated growth of WT and F384L-FGFR3-expressing B9 cells with IC50 values of 25 nM. B9-MINV cells are resistant to the inhibitory activity of Dovitinib at concentrations up to 1 μM. Dovitinib inhibits cell proliferation of KMS11 (FGFR3-Y373C), OPM2 (FGFR3-K650E), and KMS18 (FGFR3-G384D) cells with IC50 of values of 90 nM (KMS11 and OPM2) and 550 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 915769-50-5
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Molecular Weight 500.52
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Formula C24H29FN6O5
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SMILES
O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3.CC(O)C(O)=O.[H]O[H]
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Synonyms
TKI258 lactate hydrate; CHIR-258 lactate hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Commun
PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation. [Abstract]2025 Jul 24;16(1):6777. PMID: 40707483 -
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
Theranostics
Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway. [Abstract]2018 Jul 30;8(15):4262-4278. PMID: 30128052
Dovitinib lactate hydrate purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278. [Abstract]
BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.
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NPJ Precis Oncol
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer. [Abstract]2021 Jul 16;5(1):66. PMID: 34272467 -
Front Cell Dev Biol
2020 May 7:8:287. PMID: 32457900
Dovitinib lactate hydrate purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2020 May 7:8:287. [Abstract]
Determination in L3.6 cells of FGF2-induced FGFR phosphorylation by Western blot in the presence of Dovitinib. FGFR1 and alpha-Tubulin are used as loading controls.
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J Biol Chem
2023 Apr;299(4):104595 PMID: 36898579 -
BMJ Open Ophthalmol
Impact of anticancer drugs on human Tenon's fibroblast proliferation: implications for glaucoma surgery. [Abstract]2026 Jan 12;11(1):e002307. PMID: 41526033 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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