915769-50-5
915769-50-5
Chemical Structure
Dovitinib lactate hydrate
Synonym(s): TKI258 lactate hydrate; CHIR-258 lactate hydrate
- CAS No.: 915769-50-5
- Formula:C24H29FN6O5
- Molecular Weight:500.52
IUPAC Name: 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate
InChIKey: QDPVYZNVVQQULH-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3.CC(O)C(O)=O.[H]O[H]
Biological Activity: Dovitinib lactate hydrate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
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Dovitinib lactate hydrate | Dovitinib lactate hydrate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. | |||||||||||||||||||||
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