NSC 828467

Cat. No.: HY-144222: Data Sheet Handling Instructions
FAQs
Technical Support

NSC 828467 exhibited significant in vitro anticancer activity,and it is one of the top-five CA IX inhibitors with an IC₅₀ value of 27.2nM.

For research use only. We do not sell to patients.

NSC 828467 Chemical Structure

CAS No. : 3033384-72-1

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms

CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

Biological Activity
Purity & Documentation
References
Customer Review

Description

NSC 828467 exhibited significant in vitro anticancer activity,and it is one of the top-five CA IX inhibitors with an IC₅₀ value of 27.2nM.

IC₅₀ & Target

HCA IX

27.2 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	1.06 μM Compound: 5k	Anticancer activity against human 786-0 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human 786-0 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
A498	GI₅₀	1.61 μM Compound: 5k	Anticancer activity against human A498 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human A498 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
A549	GI₅₀	2.29 μM Compound: 5k	Anticancer activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
ACHN	GI₅₀	1.12 μM Compound: 5k	Anticancer activity against human ACHN cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human ACHN cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
BT-549	GI₅₀	0.89 μM Compound: 5k	Anticancer activity against human BT-549 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human BT-549 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
CAKI-1	GI₅₀	0.61 μM Compound: 5k	Anticancer activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
CCRF-CEM	GI₅₀	0.31 μM Compound: 5k	Anticancer activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
COLO 205	GI₅₀	0.41 μM Compound: 5k	Anticancer activity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
DU-145	GI₅₀	0.85 μM Compound: 5k	Anticancer activity against human DU-145 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human DU-145 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
EKVX	GI₅₀	0.71 μM Compound: 5k	Anticancer activity against human EKVX cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human EKVX cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HCC 2998	GI₅₀	0.65 μM Compound: 5k	Anticancer activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HCC 2998	IC₅₀	1.93 μM Compound: 5k	Cytotoxicity against human HCC 2998 cells assessed as inhibition of cell viability incubated for 72 hrs under hypoxia condition by MTT assay Cytotoxicity against human HCC 2998 cells assessed as inhibition of cell viability incubated for 72 hrs under hypoxia condition by MTT assay	[PMID: 35182815]
HCT-116	GI₅₀	0.39 μM Compound: 5k	Anticancer activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HCT-15	GI₅₀	1.45 μM Compound: 5k	Anticancer activity against human HCT-15 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HCT-15 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HEK293	IC₅₀	45.64 μM Compound: 5k	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability by MTT assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability by MTT assay	[PMID: 35182815]
HL-60(TB)	GI₅₀	0.63 μM Compound: 5k	Anticancer activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HOP-62	GI₅₀	0.55 μM Compound: 5k	Anticancer activity against human HOP-62 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HOP-62 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HOP-92	GI₅₀	0.8 μM Compound: 5k	Anticancer activity against human HOP-92 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HOP-92 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
HT-29	GI₅₀	2.15 μM Compound: 5k	Anticancer activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
Hs-578T	GI₅₀	1.88 μM Compound: 5k	Anticancer activity against human Hs-578T cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human Hs-578T cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
IGROV-1	GI₅₀	0.79 μM Compound: 5k	Anticancer activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
K562	GI₅₀	0.4 μM Compound: 5k	Anticancer activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
KM12	GI₅₀	2.14 μM Compound: 5k	Anticancer activity against human KM12 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human KM12 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
M14	GI₅₀	0.85 μM Compound: 5k	Anticancer activity against human M14 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human M14 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
MCF7	GI₅₀	1.1 μM Compound: 5k	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
MDA-MB-231	GI₅₀	0.5 μM Compound: 5k	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
MDA-MB-435	GI₅₀	0.91 μM Compound: 5k	Anticancer activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
MDA-MB-468	GI₅₀	0.31 μM Compound: 5k	Anticancer activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
MOLT-4	GI₅₀	0.43 μM Compound: 5k	Anticancer activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
Malme-3M	GI₅₀	1 μM Compound: 5k	Anticancer activity against human Malme-3M cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human Malme-3M cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
NCI-H226	GI₅₀	1.07 μM Compound: 5k	Anticancer activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
NCI-H23	GI₅₀	1.21 μM Compound: 5k	Anticancer activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
NCI-H322M	GI₅₀	0.4 μM Compound: 5k	Anticancer activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
NCI-H460	GI₅₀	2.41 μM Compound: 5k	Anticancer activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
NCI-H522	GI₅₀	0.45 μM Compound: 5k	Anticancer activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
NCI/ADR-RES	GI₅₀	2.75 μM Compound: 5k	Anticancer activity against human NCI/ADR-RES cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI/ADR-RES cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
OVCAR-3	GI₅₀	0.46 μM Compound: 5k	Anticancer activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
OVCAR-4	GI₅₀	0.44 μM Compound: 5k	Anticancer activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
OVCAR-5	GI₅₀	1.6 μM Compound: 5k	Anticancer activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
OVCAR-8	GI₅₀	0.44 μM Compound: 5k	Anticancer activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
PC-3	GI₅₀	0.69 μM Compound: 5k	Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
RPMI-8226	GI₅₀	2.11 μM Compound: 5k	Anticancer activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
RXF 393	GI₅₀	1.07 μM Compound: 5k	Anticancer activity against human RXF 393 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human RXF 393 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
RXF 393	IC₅₀	3.11 μM Compound: 5k	Cytotoxicity against human RXF 393 cells assessed as inhibition of cell viability incubated for 72 hrs under hypoxia condition by MTT assay Cytotoxicity against human RXF 393 cells assessed as inhibition of cell viability incubated for 72 hrs under hypoxia condition by MTT assay	[PMID: 35182815]
SF-268	GI₅₀	0.46 μM Compound: 5k	Anticancer activity against human SF-268 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SF-268 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SF-295	GI₅₀	1.4 μM Compound: 5k	Anticancer activity against human SF-295 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SF-295 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SF-539	GI₅₀	0.68 μM Compound: 5k	Anticancer activity against human SF-539 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SF-539 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SK-MEL-2	GI₅₀	1.5 μM Compound: 5k	Anticancer activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SK-MEL-28	GI₅₀	0.75 μM Compound: 5k	Anticancer activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SK-MEL-5	GI₅₀	0.78 μM Compound: 5k	Anticancer activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SK-MEL-5	IC₅₀	8.33 μM Compound: 5k	Cytotoxicity against human SK-MEL-5 cells assessed as inhibition of cell viability incubated for 72 hrs under hypoxia condition by MTT assay Cytotoxicity against human SK-MEL-5 cells assessed as inhibition of cell viability incubated for 72 hrs under hypoxia condition by MTT assay	[PMID: 35182815]
SK-OV-3	GI₅₀	0.84 μM Compound: 5k	Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SN12C	GI₅₀	1.01 μM Compound: 5k	Anticancer activity against human SN12C cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SN12C cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SNB-19	GI₅₀	0.85 μM Compound: 5k	Anticancer activity against human SNB-19 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SNB-19 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SNB-75	GI₅₀	1.32 μM Compound: 5k	Anticancer activity against human SNB-75 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SNB-75 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SR	GI₅₀	0.33 μM Compound: 5k	Anticancer activity against human SR cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SR cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
SW-620	GI₅₀	0.71 μM Compound: 5k	Anticancer activity against human SW-620 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SW-620 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
T47D	GI₅₀	0.47 μM Compound: 5k	Anticancer activity against human T47D cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human T47D cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
TK-10	GI₅₀	1.19 μM Compound: 5k	Anticancer activity against human TK-10 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human TK-10 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
U-251	GI₅₀	0.51 μM Compound: 5k	Anticancer activity against human U-251 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human U-251 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
UACC-257	GI₅₀	2.14 μM Compound: 5k	Anticancer activity against human UACC-257 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human UACC-257 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
UACC-62	GI₅₀	0.57 μM Compound: 5k	Anticancer activity against human UACC-62 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human UACC-62 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]
UO-31	GI₅₀	1.5 μM Compound: 5k	Anticancer activity against human UO-31 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human UO-31 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35182815]

Molecular Weight

461.50

Formula

C₂₁H₁₉N₉O₂S

CAS No.

3033384-72-1

SMILES

NS(=O)(C1=CC=C(C=C1)NC2=NC(N/N=C/C3=NC=CC=C3)=NC(NC4=CC=CC=C4)=N2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tawfik HO, et al. Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach. Eur J Med Chem. 2022 Feb 12;232:114190. [Content Brief]

NSC 828467 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 8284673033384-72-1NSC828467NSC-828467Carbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

Please select a local distributor ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Product Name			Requested Quantity *
Applicant Name *			Salutation
Email Address *			Phone Number *
Department			Organization Name *
City			State
Country or Region *
Remarks

Product Name			Lot #
Applicant Name *			Email Address *
Phone Number			Department *
Organization Name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

NSC 828467

NSC 828467 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Carbonic Anhydrase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

NSC 828467 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report