2. Metabolic Enzyme/Protease Apoptosis
  3. E1/E2/E3 Enzyme Apoptosis
  4. SZL P1-41

SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities.

For research use only. We do not sell to patients.

CAS No. : 222716-34-9

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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of SZL P1-41:

SZL P1-41 Related Antibodies

Top Publications Citing Use of Products

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606.  [Abstract]

    Dual inhibition of Aur-A and SKP2 significantly increased protein levels of C-Cas-3, p21, p27, FOXO3A and decreased p-Aur-A, SKP2 and p-FOXO3A in ccRCC cells. 769-P cells were treated with MLN8237 (10 μM) or SZL P1-41 (20 μM), or combination of the two compounds, followed by the IB assay with indicated antibodies.

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606.  [Abstract]

    Immunohistochemical staining of xenograft tumor tissues. Tumor tissues from four groups of nude mice were fixed, sectioned, and stained with indicated antibodies treated with SZL P1-41 (80 mg/kg/day of every day for 4 weeks).

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606.  [Abstract]

    The tumors were harvested and tumor growth was monitored treated with SZL P1-41 (80 mg/kg/day of every day for 4 weeks).

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606.  [Abstract]

    Combination of MLN8237 and SZL P1-41 inhibited clonogenic ability in ccRCC cells. 769-P cells were treated with MLN8237 (10 μM) or SZL P1-41 (20 μM) alone or combination of the two compounds, followed by the colony formation assay.

    SZL P1-41 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 13;13(7):606.  [Abstract]

    IC50 values of SZL P1-41 (0, 0.39, 0.78, 1.56, 3.125, 6.25, 12.5, 25, 50, and 100 μM, 48 h) in five ccRCC cell lines and HK-2 cell line by the CCK-8 assay.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2].

    IC50 & Target

    Skp2[1]
    In Vitro

    SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SZL P1-41 Related Antibodies
    In Vivo

    SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    420.52

    Formula

    C24H24N2O3S
    CAS No.
    Appearance

    Solid

    Color

    Off-white to pink

    SMILES

    O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 2.5 mg/mL (5.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3780 mL 11.8900 mL 23.7801 mL
    5 mM 0.4756 mL 2.3780 mL 4.7560 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  Corn Oil

      Solubility: 5 mg/mL (11.89 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3780 mL 11.8900 mL 23.7801 mL 59.4502 mL
    5 mM 0.4756 mL 2.3780 mL 4.7560 mL 11.8900 mL
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    SZL P1-41 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SZL P1-41222716-34-9E1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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    Product Name:
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