CD367/CLEC4A Protein, Mouse (HEK293, Fc)

CD367/CLEC4A protein may regulate immune responses and affect dendritic cell (DC) differentiation. As a C-type lectin receptor, it binds carbohydrates and interacts weakly with N-acetylglucosamine. CD367/CLEC4A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD367/CLEC4A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD367/CLEC4A Protein, Mouse (HEK293, Fc) is 169 a.a., with molecular weight of 60-65 kDa.

The CD367/CLEC4A protein potentially plays a role in regulating immune reactivity and may have implications in modulating the differentiation and maturation of dendritic cells (DC). It is a C-type lectin receptor that can bind to carbohydrates such as mannose and fucose, as well as weakly interact with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. CD367/CLEC4A is involved in inhibiting B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Upon antigen stimulation, it undergoes clathrin-dependent endocytosis, delivering its antigenic cargo into the antigen presentation pathway and promoting cross-priming of CD8(+) T cells. This cross-presentation and cross-priming process can be enhanced by TLR7 and TLR8 agonists, resulting in increased expansion of CD8(+) T cells and high production of IFNG and TNF, while reducing levels of IL4, IL5, and IL13. In plasmacytoid dendritic cells, CD367/CLEC4A inhibits TLR9-mediated production of IFNA and TNF. Furthermore, its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) may contribute to the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.

Mouse

HEK293

C-hFc

Q9QZ15 (Q70-L238)

26888  [NCBI]

60-65 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.