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Results for "

PA N-oxide,hepatocarcinogenic,pyrrolizidine alkaloid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (24) Acyltransferase (2) ADC Payload (6) Adenosine Receptor (4) Adiponectin Receptor (1) Adrenergic Receptor (22) Akt (35) Aldose Reductase (1) Aminotransferases (Transaminases) (1) AMPK (9) Amyloid-β (9) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (31) AP-1 (6) Apoptosis (159) Arginase (1) Arp2/3 Complex (1) Atg7 (1) Atg8/LC3 (1) Autophagy (80) Bacterial (133) Bcl-2 Family (11) Beclin1 (1) Beta-lactamase (2) Beta-secretase (4) Biochemical Assay Reagents (42) c-Met/HGFR (1) c-Myc (1) Calcium Channel (12) Cannabinoid Receptor (1) Caspase (18) CDK (9) CHIKV (1) Cholinesterase (ChE) (60) Collagen (1) COX (12) CXCR (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (16) Dengue Virus (10) Dihydroorotate Dehydrogenase (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (12) Dopamine Receptor (10) Drug Derivative (122) Drug Intermediate (19) Drug Isomer (10) Drug Metabolite (11) DYRK (3) E1/E2/E3 Enzyme (3) EBV (1) EGFR (1) Endogenous Metabolite (72) Enterovirus (4) Environmental Pollutants (7) ERK (9) Fatty Acid Synthase (FASN) (2) Ferroptosis (16) Filovirus (5) Flavivirus (14) Free Fatty Acid Receptor (2) Fungal (58) GABA Receptor (17) GLUT (1) Glutamate Dehydrogenase (GLDH) (1) Glutaminase (1) Glutathione Peroxidase (2) Glutathione S-transferase (4) Glycosidase (5) GSK-3 (5) HBV (4) HCV (1) Hedgehog (2) Heme Oxygenase (HO) (3) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (1) Histone Methyltransferase (1) HIV (20) HSP (4) HSV (3) ICMT (1) iGluR (4) IKK (6) Imidazoline Receptor (5) Indoleamine 2,3-Dioxygenase (IDO) (5) Influenza Virus (23) Insecticide (5) Integrin (1) Interleukin Related (35) IRE1 (2) Isotope-Labeled Compounds (37) JAK (10) JNK (20) Keap1-Nrf2 (9) LDLR (2) Leukotriene Receptor (2) Liposome (1) Lipoxygenase (3) mAChR (31) MAPKAPK2 (MK2) (3) MARK (1) MDM-2/p53 (5) MEK (1) Melanocortin Receptor (1) METTL3 (1) mGluR (1) MicroRNA (3) Microtubule/Tubulin (19) Mitochondrial Metabolism (5) Mitophagy (4) Mitosis (3) MMP (11) Monoamine Oxidase (22) mTOR (9) MyD88 (2) Na+/Ca2+ Exchanger (1) nAChR (46) Necroptosis (1) NF-κB (72) NO Synthase (23) NOD-like Receptor (NLR) (6) Opioid Receptor (20) Oxidative Phosphorylation (2) P-glycoprotein (13) P2X Receptor (2) p38 MAPK (33) PAI-1 (2) Parasite (84) PARP (4) PD-1/PD-L1 (1) PDGFR (1) PERK (3) PGE synthase (6) Phosphatase (1) Phosphodiesterase (PDE) (11) PI3K (26) Pim (1) PINK1/Parkin (6) PKC (6) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Potassium Channel (25) PPAR (1) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (1) Proteasome (1) Protein Arginine Deiminase (2) Proton Pump (4) Pyruvate Kinase (1) RAD51 (2) Raf (1) RANKL/RANK (2) Ras (1) Reactive Oxygen Species (ROS) (61) Reference Standards (161) Reverse Transcriptase (3) ROCK (2) ROS Kinase (3) RSV (2) SARS-CoV (3) Ser/Thr Protease (1) Serotonin Transporter (2) Sigma Receptor (2) Sirtuin (4) Smo (2) SOD (5) Sodium Channel (7) STAT (16) STING (2) Tau Protein (1) TGF-beta/Smad (4) Thrombin (2) TMV (2) TNF Receptor (15) Toll-like Receptor (TLR) (8) Topoisomerase (28) TREM receptor (1) Trk Receptor (1) TRP Channel (3) Tyrosinase (5) VEGFR (6) Virus Protease (4) Wnt (7) YAP (2) α-synuclein (7) β-catenin (7) β-glucuronidase (2) γ-secretase (1)
By Research Areas:	Cancer (409) Cardiovascular Disease (114) Endocrinology (20) Infection (281) Inflammation/Immunology (307) Metabolic Disease (117) Neurological Disease (335)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Liposome (1)

1599

Inhibitors & Agonists

Bibliothèques de criblage

Biochemical Assay Reagents

Peptides

1375

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-W783671

Perlolyrin Tribulusterine	Drug Derivative	Others
Perlolyrin (Tribulusterine) is an alkaloid that can be isolated from dried fruits of Tribulus terrestris .

HY-N8052

(-)-Antofine	Fungal	Infection
(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound .

HY-N1999

Wilfordine	Others	Others
Wilfordine is an alkaloid that isolated from the roots of Tripterygium wilfordii .

HY-N9794

Isoboldine	Others	Inflammation/Immunology
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-W705106

(-)-Coclaurine hydrochloride 1 Publications Verification (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride	nAChR	Neurological Disease
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-123077

Norsanguinarine	Fungal	Infection
Norsanguinarine, an alkaloid, has antifungal activity against Alternaria brassicicola, Curvularia maculans at 1000 ppm .

HY-B1181

Hydrastinine hydrochloride	Others	Cardiovascular Disease
Hydrastinine hydrochloride is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine hydrochloride can be used as a haemostatic agent .

HY-N7625

N-Formylcytisine	Others	Metabolic Disease
N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis .

HY-N16521

Thalifaronine	Others	Others
Thalifaronine is an alkaloid. Thalifaronine can be isolated from Thalictrum faberi .

HY-117190

Pseudolycorine	Others	Cancer
Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity .

HY-N9130

Indicine	Others	Others
Indicine (Compound 3) is an alkaloid. Indicine can reduce pyrrolizine alkaloids (PA) .

HY-N3735

Deoxyvasicinone 9-Oxodeoxypeganine; Pegenone	Others	Others
Deoxyvasicinone is an alkaloid compound isolated from plants .

HY-N2637

Yibeinoside A	Others	Others
Yibeinoside A is an alkaloid isolated from the bulb of Fritillaria pallidiflora Schreb .

HY-N11922

Ipalbidine	Others	Neurological Disease
Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects .

HY-117396

Isomahanimbine	Others	Others
Isomahanimbine is a natural carbazole alkaloid found in Murraya koenigii (L.) Spreng .

HY-118425

(+)-Adlumine O-Methylcorledine	Drug Derivative	Others
(+)-Adlumine (O-Methylcorledine) is an alkaloid derivative found in Corydalis ledebouriana .

HY-W017353

Pseudopelletierine	Biochemical Assay Reagents	Others
Pseudopelletierine is an alkaloid compound that can be used as a enzyme substrate .

HY-N7792

Baptifoline	Others	Others
Baptifoline is an alkaloid isolated from the rhizome of Caulophyllum thalictroides .

HY-N10376

Lagunamine 19-Hydroxytubotaiwine	Others	Infection Cancer
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

HY-116590

(±)-Glaziovine	VEGFR	Neurological Disease
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .

HY-N17338

Nupharamine (-)-Nupharamine	Others	Others
Nupharamine ((-)-Nupharamine) is an alkaloid. Nupharamine can be isolated from the root of Nuphar japonicum DC .

HY-N11131

9-O-Methylstecepharine	Others	Others
9-O-Methylstecepharine (compound 7) is an alkaloid that can be found in Stephania cepharantha .

HY-B1181A

Hydrastinine	Others	Cardiovascular Disease
Hydrastinine is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine can be used as a haemostatic agent .

HY-N16419

Haenamindole	Drug Derivative	Infection Cancer
Haenamindole is an alkaloid. Haenamindole is promising for research of bacterial infection and cancers .

HY-N1099

Vellosimine (+)-Vellosimine; alkaloid RB 19	Others	Others
Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite .

HY-N15615

Coromandaline	Others	Others
Coromandaline is an alkaloid found in Heliotropium curassavicum .

HY-N11979

Dihydronitidine	Others	Others
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .

HY-W653954

Littorine hydrochloride	Drug Derivative	Others
Littorine hydrochloride is an alkaloid that can be found in Anthocercis fittorea and Datura species .

HY-N3177

Norglaucine hydrochloride	Others	Others
Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .

HY-N1293

Serpentinine NSC72123	Others	Others
Serpentinine (NSC72123) is an alkaloid isolated from Rauwolfia serpentina Benth .

HY-N3281

Methyl chanofruticosinate	Others	Others
Methyl chanofruticosinate is an indole alkaloid that can be isolated from Kopsia .

HY-119478

Lophophorine	Others	Others
Lophophorine is a natural alkaloid compound .

HY-N2886

Aporeine Aporheine; S-(+)-Roemerine; d-Isoremerine	Others	Others
Aporeine (Aporheine) is an alkaloid that can be isolated from the aerial parts of p. rhoeas .

HY-N3382

Shihulimonin A	Others	Others
Shihulimonin A is an alkaloid can be isolated from the fruit of Euodia rutaecarpa (Juss.) Benth .

HY-N15627

Xanthevodine NSC 94652	Others	Others
Xanthevodine (NSC 94652) is an alkaloid that can be extracted from the leaves of Acronychia baueri Schott .

HY-121703

Rutacridone	Others	Others
Rutacridone is an alkaloid that can be cultured from Ruta graveolens L. strain R-19 .

HY-N12343

Tetrahydrorhombifoline	Bacterial Fungal	Infection
Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities .

HY-N3203

Neolinine	Others	Others
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .

HY-W482839

Glycosminine	Biochemical Assay Reagents	Others
Glycosminine is a quinazoline alkaloid found in Glycosmis arborea .

HY-N3904

Fortuneine	Others	Others
Fortuneine is a homoerythrina alkaloid from Cephalotaxus fortunei .

HY-N7722

Demethyl Calyciphylline A	Others	Others
Demethyl Calyciphylline A is an alkaloid. Demethyl Calyciphylline A can be isolated from the fruit of Daphniphyllum longacemosum K. Rosenthal .

HY-N12244

Echitaminic acid	Others	Others
Echitaminic acid (compound 3) is an alkaloid isolated from the trunk bark of Alstonia sellers collected in Timor, Indonesia .

HY-N10296

Curvulamine A	Bacterial	Infection
Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity .

HY-N11931

Grandivine A	Others	Cancer
Grandivine A is a steroid alkaloid isolated from Veratrum grandiflorum .

HY-N10763

N-Methylcorydaldine	Others	Endocrinology
N-Methylcorydaldine, an alkaloid, shows promising anti-secretory activity .

HY-N15580

Turneforcidine (-)-Turneforcidine	Others	Cancer
Turneforcidine ((-)-Turneforcidine) is a pyrrolizidine alkaloid with antitumor and cytotoxic activity .

HY-N3620

Epiquinamine Conquinamine	Parasite	Infection
Epiquinamine, an alkaloid, has amoebicidal activity (IC₅₀: 12.9 μg/mL) .

HY-N11803

Arundanine	Others	Others
Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .

HY-N8916

Coulteropine	Bacterial	Infection
Coulteropine is a natural alkaloid with antimicrobial activities .

HY-119831

Rohitukine	NF-κB	Inflammation/Immunology
Rohitukine is an alkaloid with analgesic and anti-inflammatory activities .

Cat. No.	Nom du produit

HY-L071

Alkaloids Library

600 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 600 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L0120V

Asinex BioDesign Library

170,269 compounds

“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.

Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

HY-L021

Natural Product Library

4,995 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 4,995 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L163

FDA-Approved Traditional Chinese Medicine Active Compound Library

307 compounds

Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability.

MCE designs a unique collection of 307 FDA/EMA/NMPA/PMDA etc-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

HY-L021M

Natural Product and Natural Product-Like Compound Library

5,040 compounds

From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research.

MCE provides a unique collection of 5,040 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

HY-L021P

Natural Product Library Plus

6,205 compounds

MCE provides a unique collection of 6,205 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L0107V

Life Chemicals Natural Product-like Compound Library

13,236 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.

HY-L042

Glycoside Compound Library

896 compounds

Glycosides are compounds in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Many biologically active compounds are glycosides. Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids, antibiotics, etc. The glycosidic residue can be crucial for their activity or can only improve pharmacokinetic parameters. Glycosides, which exhibit anti-inflammatory, anti-infection, anti-cancer and anti-oxidative properties, play numerous important roles in living organisms, such as streptomycin, as an aminoglycoside antibiotic, has anti-infection activity. Anthracyclines possess good antibacterial and anti-cancer activities.

MCE Glycoside Compound Library contains a unique collection of 896 glycoside compounds and is a useful tool to discovery glycoside drugs.

HY-L200

RO5 Drug-like Natural Product Library

2,820 compounds

Natural products are small molecular compounds that occur in nature and come from any organism, including primary and secondary metabolites. Natural products have potential biological activity and can be used as lead compounds for drug discovery. Nature has been a source of medicines for thousands of years, and a large number of drugs have been isolated from nature, many based on their use in traditional medicine. With the development of compound targets, there is an increasing need to screen for compound diversity. Through ongoing research into natural biodiversity, much of which remains to be exploited, natural products will play a key role in meeting this demand. The Lipinski rule of 5 is used to describe the drug-like properties of a molecule, molecules that adhere to the rule of 5 have higher drug potential. Based on MCE natural product library, MCE selects the molecules that obey the rule of 5, which makes the efficiency of drug screening higher.

MCE designs a unique collection of 2,820 RO5 drug-like natural products, which is an important tool for drug discovery.

HY-L065

Traditional Chinese Medicine Active Compound Library

3,255 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 3,255 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

Cat. No.	Nom du produit	Type

HY-W014971

Tryptamine hydrochloride

1 Publications Verification

Biochemical Assay Reagents

Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-119575

Tetramethyluric acid 1,3,7,9-Tetramethyluric acid; Theacrine	Biochemical Assay Reagents
Tetramethyluric acid (1,3,7,9-Tetramethyluric acid) is an orally active purine alkaloid in Coffea species and Camellia kucha. Tetramethyluric acid exhibits antiviral, and anti-inflammatory activity. Tetramethyluric acid can be used for the research of inflammation disease, and influenza virus infection .

HY-159051

Dragendorff reagent	Biochemical Assay Reagents
Dragendorff reagent is used for detecting alkaloids and other nitrogen-containing compounds. Dragendorff reagent is a solution of potassium bismuth iodide composing of Basic bismuth nitrate (Bi(NO₃)₃), Tartaric acid (HY-N2436), and Potassium iodide (KI). When contact with alkaloids, Dragendorff reagent produces an orange or orange red precipitate .

HY-16569B

Colchicine,suitable for plant cell culture

Biochemical Assay Reagents

Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture .

HY-32786

6-Bromonicotinaldehyde	Biochemical Assay Reagents
6-Bromonicotinaldehyde is a brominated derivative of nicotinaldehyde (pyridine-3-aldehyde), and it can be used as a key intermediate in the synthesis of Fusaric acid .

HY-W127746

Picrolonic acid	Biochemical Assay Reagents
Picrolonic acid is the reagent for the separation of amines as crystalline π-complexes. Pyrrolic acid is an analytical reagent for the determination of calcium, magnesium, lead, strontium and thorium. It is also used for the analysis of alkaloids, tryptophan and phenylalanine.

HY-W749852

Xanthine sodium, 98%	Biochemical Assay Reagents
Xanthine sodium, 98%, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, 98% also acts as an intermediate product on the pathway of purine degradation .

HY-W017353

Pseudopelletierine	Biochemical Assay Reagents
Pseudopelletierine is an alkaloid compound that can be used as a enzyme substrate .

HY-W001288

Indole-4-carboxaldehyde

Biochemical Assay Reagents

Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis .

HY-W749852A

Xanthine sodium, for cell culture	Biochemical Assay Reagents
Xanthine sodium, for cell culture, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, for cell culture also acts as an intermediate product on the pathway of purine degradation .

HY-W142402

cis-Aconitic anhydride	Biochemical Assay Reagents
cis-Aconitic anhydride, in the presence of acetic anhydride, can be used to detect and determine aliphatic tert-amines and alkaloids. Cis-aconitine anhydride reacts with aliphatic tertiary amines in alcoholic solution to form a yellow color .

Cat. No.	Nom du produit	Target	Research Area

HY-P1936

Cyclo(Gly-L-Pro)	Peptides	Others
Cyclo(Gly-L-Pro) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

HY-N11955

Cyclo(Ile-Leu)	Peptides	Others
Cyclo(Ile-Leu) is a Alkaloids product that can be isolated from From Penicillium oxalicum .

HY-P5751

Cyclo(Ile-Val)	Peptides	Others
Cyclo(Ile-Val) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-W783671

Perlolyrin Tribulusterine	Tribulus terrester Linn. Structural Classification Alkaloids Pyrrole Alkaloids Zygophyllaceae Plants Source Classification	Drug Derivative
Perlolyrin (Tribulusterine) is an alkaloid that can be isolated from dried fruits of Tribulus terrestris .

HY-N3398

Lauroscholtzine N-Methyllaurotetanine	Alkaloids Thalictrum revolutum DC. Ranunculaceae Plants Isoquinoline Alkaloids Source Classification	5-HT Receptor
Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist .

HY-N8052

(-)-Antofine	Alkaloids Pyrrole Alkaloids Asclepiadaceae Cynanchum paniculatum (Bunge) Kitagawa Plants Source Classification	Fungal
(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound .

HY-N1999

Wilfordine	Classification of Application Fields Terpenoids Sesquiterpenes Celastraceae Other Diseases Tripterygium wilfordii Hook. f. Plants Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Others
Wilfordine is an alkaloid that isolated from the roots of Tripterygium wilfordii .

HY-N9794

Isoboldine	Alkaloids Piperidine Alkaloids Phenols Polyphenols Plants Lauraceae Lindera aggregata (Sims) Kosterm. Source Classification	Others
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-W705106

(-)-Coclaurine hydrochloride 1 Publications Verification (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride	Alkaloids Piperidine Alkaloids Cocculus laurifolius DC. Plants Menispermaceae Source Classification	nAChR
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .

HY-123077

Norsanguinarine	Infection Alkaloids Classification of Application Fields Plants Papaver somniferum Linn. Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Fungal
Norsanguinarine, an alkaloid, has antifungal activity against Alternaria brassicicola, Curvularia maculans at 1000 ppm .

HY-B1181

Hydrastinine hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Guttiferae Ranunculaceae Plants Isoquinoline Alkaloids Disease Research Fields Hypericum monogynum L. Source Classification	Others
Hydrastinine hydrochloride is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine hydrochloride can be used as a haemostatic agent .

HY-N7625

N-Formylcytisine	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Maackia hupehensis Takeda Metabolic Disease Maackia amurensis Rupr. et Maxim. Plants Disease Research Fields Source Classification	Others
N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis .

HY-N16521

Thalifaronine	Structural Classification Alkaloids Microorganisms Isoquinoline Alkaloids Source Classification	Others
Thalifaronine is an alkaloid. Thalifaronine can be isolated from Thalictrum faberi .

HY-117190

Pseudolycorine	Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Plants Isoquinoline Alkaloids Amaryllidaceae Source Classification	Others
Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity .

HY-N9130

Indicine	Alkaloids Other Alkaloids Plants Heliotropium amplexicaule Vahl Boraginaceae Source Classification	Others
Indicine (Compound 3) is an alkaloid. Indicine can reduce pyrrolizine alkaloids (PA) .

HY-N3735

Deoxyvasicinone 9-Oxodeoxypeganine; Pegenone	Alkaloids Classification of Application Fields Zygophyllaceae Peganum harmala Linn. Other Diseases Plants Disease Research Fields Source Classification	Others
Deoxyvasicinone is an alkaloid compound isolated from plants .

HY-N2637

Yibeinoside A	Alkaloids other families Classification of Application Fields Other Diseases Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Others
Yibeinoside A is an alkaloid isolated from the bulb of Fritillaria pallidiflora Schreb .

HY-N11922

Ipalbidine	Alkaloids Monophenols Other Alkaloids Phenols Plants Convolvulaceae Ipomoea alba Linnaeus Source Classification	Others
Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects .

HY-117396

Isomahanimbine	Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids	Others
Isomahanimbine is a natural carbazole alkaloid found in Murraya koenigii (L.) Spreng .

HY-118425

(+)-Adlumine O-Methylcorledine	Structural Classification Alkaloids Corydalis mucronifera Maxim. Plants Isoquinoline Alkaloids Papaveraceae Source Classification	Drug Derivative
(+)-Adlumine (O-Methylcorledine) is an alkaloid derivative found in Corydalis ledebouriana .

HY-N7792

Baptifoline	Alkaloids Leguminosae Genista quadriflora Munby Plants Source Classification	Others
Baptifoline is an alkaloid isolated from the rhizome of Caulophyllum thalictroides .

HY-N10376

Lagunamine 19-Hydroxytubotaiwine	Apocynaceae Alstonia scholaris (L.) R. Br. Plants Source Classification	Others
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

HY-116590

(±)-Glaziovine	Alkaloids Other Alkaloids Unonopsis duckei R.E.Fr. Plants Annonaceae Source Classification	VEGFR
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .

HY-N17338

Nupharamine (-)-Nupharamine	Structural Classification Alkaloids Other Alkaloids Nuphar japonica DC. Plants Nymphaeaceae Source Classification	Others
Nupharamine ((-)-Nupharamine) is an alkaloid. Nupharamine can be isolated from the root of Nuphar japonicum DC .

HY-N11131

9-O-Methylstecepharine	Alkaloids Stephania cepharantha Hayata Pyrrole Alkaloids Plants Menispermaceae Source Classification	Others
9-O-Methylstecepharine (compound 7) is an alkaloid that can be found in Stephania cepharantha .

HY-B1181A

Hydrastinine	Cardiovascular Disease Alkaloids Classification of Application Fields Ranunculaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Others
Hydrastinine is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine can be used as a haemostatic agent .

HY-N16419

Haenamindole	Alkaloids Microorganisms Other Alkaloids Source Classification	Drug Derivative
Haenamindole is an alkaloid. Haenamindole is promising for research of bacterial infection and cancers .

HY-N1099

Vellosimine (+)-Vellosimine; alkaloid RB 19	Alkaloids other families Pteris wallichiana Agardh Plants Indole Alkaloids Source Classification	Others
Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite .

HY-N15615

Coromandaline	Alkaloids Other Alkaloids Plants Boraginaceae Heliotropium curassavicum L. Source Classification	Others
Coromandaline is an alkaloid found in Heliotropium curassavicum .

HY-N11979

Dihydronitidine	Alkaloids Other Alkaloids Rutaceae Zanthoxylum rhoifolium Lam. Plants Source Classification	Others
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .

HY-N3177

Norglaucine hydrochloride	Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids Source Classification	Others
Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .

HY-N1293

Serpentinine NSC72123	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Alkaloids Rauvolfia serpentina Plants Indole Alkaloids Source Classification	Others
Serpentinine (NSC72123) is an alkaloid isolated from Rauwolfia serpentina Benth .

HY-N3281

Methyl chanofruticosinate	Apocynaceae Alkaloids Plants Indole Alkaloids Source Classification Kopsia Blume	Others
Methyl chanofruticosinate is an indole alkaloid that can be isolated from Kopsia .

HY-119478

Lophophorine	Alkaloids Cactaceae Other Alkaloids Lophophora williamsii (Lem. ex Salm-Dyck) J. M. Coult. Plants Source Classification	Others
Lophophorine is a natural alkaloid compound .

HY-N2886

Aporeine Aporheine; S-(+)-Roemerine; d-Isoremerine	Alkaloids Piperidine Alkaloids Plants Papaveraceae Source Classification	Others
Aporeine (Aporheine) is an alkaloid that can be isolated from the aerial parts of p. rhoeas .

HY-N3382

Shihulimonin A	Productos naturales Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley Source Classification	Others
Shihulimonin A is an alkaloid can be isolated from the fruit of Euodia rutaecarpa (Juss.) Benth .

HY-N15627

Xanthevodine NSC 94652	Structural Classification Alkaloids Rutaceae Quinoline Alkaloids Plants Melicope vitiflora (F.Muell.) T.G.Hartley Source Classification	Others
Xanthevodine (NSC 94652) is an alkaloid that can be extracted from the leaves of Acronychia baueri Schott .

HY-121703

Rutacridone	Alkaloids Boenninghausenia albiflora (Hook.) Reichb. ex Meisn. Other Alkaloids Rutaceae Plants Source Classification	Others
Rutacridone is an alkaloid that can be cultured from Ruta graveolens L. strain R-19 .

HY-N12343

Tetrahydrorhombifoline	Alkaloids Leguminosae Other Alkaloids Genista vuralii A.Duran & Dural Plants Source Classification	Bacterial Fungal
Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities .

HY-N3203

Neolinine	Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Others
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .

HY-W482839

Glycosminine	Alkaloids Quinazoline Alkaloids Glycosmis arborea (Retz.) Corrêa Rutaceae Plants Source Classification	Biochemical Assay Reagents
Glycosminine is a quinazoline alkaloid found in Glycosmis arborea .

HY-N3904

Fortuneine	Alkaloids Classification of Application Fields Other Diseases Plants Cephalotaxaceae Isoquinoline Alkaloids Disease Research Fields Source Classification Cephalotaxus fortunei Hooker	Others
Fortuneine is a homoerythrina alkaloid from Cephalotaxus fortunei .

HY-N7722

Demethyl Calyciphylline A	Alkaloids Daphniphyllum longeracemosum Rosenth. Pyrrole Alkaloids Plants Source Classification	Others
Demethyl Calyciphylline A is an alkaloid. Demethyl Calyciphylline A can be isolated from the fruit of Daphniphyllum longacemosum K. Rosenthal .

HY-N12244

Echitaminic acid	Apocynaceae Alkaloids Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids Source Classification	Others
Echitaminic acid (compound 3) is an alkaloid isolated from the trunk bark of Alstonia sellers collected in Timor, Indonesia .

HY-N10296

Curvulamine A	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Bacterial
Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity .

HY-N11931

Grandivine A	Alkaloids Veratrum grandiflorum Loes. Other Alkaloids Plants Melanthiaceae Source Classification	Others
Grandivine A is a steroid alkaloid isolated from Veratrum grandiflorum .

HY-N10763

N-Methylcorydaldine	Michelia figo (Lour.) Spreng. Magnoliaceae Plants Source Classification	Others
N-Methylcorydaldine, an alkaloid, shows promising anti-secretory activity .

HY-N15580

Turneforcidine (-)-Turneforcidine	Alkaloids Pyrrole Alkaloids Leguminosae Plants Source Classification Crotalaria candicans Wight & Arn.	Others
Turneforcidine ((-)-Turneforcidine) is a pyrrolizidine alkaloid with antitumor and cytotoxic activity .

HY-N3620

Epiquinamine Conquinamine	Cinchona succirubra Pav. ex Klotzsch Alkaloids Rubiaceae Plants Source Classification	Parasite
Epiquinamine, an alkaloid, has amoebicidal activity (IC₅₀: 12.9 μg/mL) .

HY-N11803

Arundanine	Alkaloids Gramineae Plants Arundo donax Linn. Indole Alkaloids Source Classification	Others
Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .

HY-N8916

Coulteropine	Alkaloids Romneya coulteri Harv. Other Alkaloids Plants Papaveraceae Source Classification	Bacterial
Coulteropine is a natural alkaloid with antimicrobial activities .

HY-N11918

Jervinone	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Jervinone is a metabolite of the Veratrum alkaloid, which can be isolated from the mold Cunninghamella echinulata .

HY-N15702

Dichotomine A (S)-(-)-Dichotomine A	Alkaloids Stellaria dichotoma L. Plants Caryophyllaceae Indole Alkaloids Source Classification	Others
Dichotomine A ((S)-(-)-Dichotomine A) is a β-carboline-type alkaloid found in the roots of Stellaria dichotoma .

Cat. No.	Nom du produit	Chemical Structure

HY-B2132S1

Tryptamine-d4 hydrochloride
Tryptamine-d₄ (hydrochloride) is the deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride, a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .

HY-W017389S

Xanthine-13C,15N2
Xanthine- ¹³C, ¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .

HY-N0415S

Trigonelline-d3 chloride
Trigonelline-d₃ (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.

HY-W012732S

Isoquinoline-d7
Isoquinoline-d₇ is the deuterium labeled Isoquinoline . Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .

HY-N0113S

Hordenine-d6
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-W001909S

Myosmine-d4
Myosmine-d₄ is the deuterium labeled Myosmine. Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a K_i of 3300 nM .

HY-N6637S

*Senecionine N-oxide-d3*
Senecionine N-oxide-d₃ is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-W017389S1

Xanthine-15N2
Xanthine- ¹⁵N₂ is a ¹⁵N-labeled Xanthine (HY-W017389) . Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .

HY-16560S

Camptothecin-d5

Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-50936S

Trabectedin-d3

Trabectedin D₃ (Ecteinascidin 743 D₃) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-W654320

Piperin-d10
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-W654256

Matrine-d3

Matrine-d₃ (Matridin-d₃) is a deuterium labeled Matrine (HY-N0164). Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-124412S

Paynantheine-d3
Paynantheine-d₃ is a deuterium labeled Paynantheine. Paynantheine is an alkaloid that can be isolated from Mitragyna speciosa. Paynantheine can decrease alcohol intake in mice .

HY-N0221S

Daurisoline-d2
Daurisoline-d₂ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer .

HY-N0221S2

Daurisoline-d11
Daurisoline-d₁₁ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer .

HY-N0221S1

Daurisoline-d5
Daurisoline-d₅ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer .

HY-B2132S

Tryptamine-d2 hydrochloride
Tryptamine-d₂ (hydrochloride) is a deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .

HY-N9512S

*Lycopsamine N-oxide-d3*
Lycopsamine N-oxide-d₃ is the deuterium labeled Lycopsamine N-oxide. Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-W004515S

3-Pyridylacetic acid-d4 hydrochloride
3-Pyridylacetic acid-d₄ (hydrochloride) is the deuterium labeled 3-Pyridylacetic acid hydrochloride . 3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids) .

HY-126047AS

(R,S)-Anatabine-d4
(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .

HY-N0471S

L-Hyoscyamine-d3
L-Hyoscyamine-d₃ is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-N2393S

Kukoamine B-d5 dihydrochloride
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .

HY-W740245

Arecaidine-d5 hydrobromide
Arecaidine-d₅ hydrobromide is the deuterium labeled Arecaidine hydrobromide (HY-N2368B). Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-W740048

Quinine-d3
Quinine-d₃ is the deuterium labeled Quinine (HY-D0143). Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC₅₀ of 169 μM .

HY-W743727

Cytisine-d4
Cytisine-d₄ is the deuterium labeled Cytisinicline (HY-N0175). Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs , and partial to full agonist at β4 containing receptors and α7 receptors . Has been used medically to help with smoking cessation .

HY-W768895

Sanguinarine chloride-13C,d3

Sanguinarine chloride- ¹³C,d₃ (Sanguinarin chloride- ¹³C,d₃) is the deuterium labeled Sanguinarine chloride (HY-N0052A). Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-W750902

Oxymatrine-d3

Oxymatrine-d₃ is the deuterium labeled Oxymatrine (HY-N0158). Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-A0009S

Galanthamine-d3 hydrobromide

Galanthamine-d₃ (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-13716S

Noscapine-13C,d3

Noscapine- ¹³C,d₃ is a ¹³C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-W700241

Norharman-d7

Norharman-d₇ is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) .

HY-W012732S2

Isoquinoline-15N

Isoquinoline- ¹⁵N is the ¹⁵N-labeled Isoquinoline (HY-W012732). Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities.

HY-126047S

(R,S)-Anatabine-d4 hydrochloride
(R,S)-Anatabine-d₄ hydrochloride is the deuterium labeled (R,S)-Anatabine hydrochloride (HY-126047A). (R,S)-Anatabine is a a minor tobacco alkaloid found in the?Solanaceae?family of?plants?that can be used as a specific marker for the detection of tobacco use.

HY-N0471S1

L-Hyoscyamine-d3-1
L-Hyoscyamine-d₃-1 (Hyoscyamine-d₃) is the deuterium labeled L-Hyoscyamine (HY-N0471). L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .

HY-W739837

Arecoline-d5 hydrobromide
Arecoline-d₅ hydrobromide is the deuterium labeled Arecoline hydrobromide (HY-B0489). Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress .

HY-N2359S

Chelerythrine-d6 chloride

Chelerythrine-d₆ is the deuterium labeled Chelerythrine (HY-N2359). Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with an IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine triggers apoptosis and autophagy .

HY-N0415S1

Trigonelline-d3-1 chloride

Trigonelline-d₃-1 chloride (Trigonelline-d₃-1 hydrochloride) is the deuterium labeled Trigonelline chloride (HY-N0415). Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-W014971S

Tryptamine-d2-1 hydrochloride

Tryptamine-d₂-1 hydrochloride is the deuterium labeled Tryptamine hydrochloride (HY-W014971). Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-N0166S

Gramine-d2

Gramine-d₂ is the deuterium labeled Gramine . Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-W001288S

Indole-4-carboxaldehyde-13C

Indole-4-carboxaldehyde- ¹³C is the ¹³C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis .

HY-W008566S

Norharmane-13C

Norharmane- ¹³C (Norharman- ¹³C) is the ¹³C-labeled Norharmane (HY-W008566). Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

Cat. No.	Nom du produit		Classification

HY-124503

Longanlactone		Alkynes
Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells .

Cat. No.	Nom du produit		Classification

HY-185399

Vincristine sulfate liposome Liposomal vincristine sulfate		Liposome
Vincristine sulfate liposome is?a liposome-encapsulated form of Vincristine sulfate (HY-N0488), an antitumor vinca alkaloid. Vincristine sulfate liposome can prolong the drug's circulation time in the body and release the drug slowly at the tumor blood vessels.

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PA N-oxide,hepatocarcinogenic,pyrrolizidine alkaloid

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