Isoharringtonine
Isoharringtonine is a natural alkaloid that can be purified from Cephalotaxus koreana Nakai. Isoharringtonine can inhibit cancer cell proliferation and migration, and induce cancer cell apoptosis. Isoharringtonine can be used for the research of cancers.
For research use only. We do not sell to patients.
- CAS No.: 26833-86-3
- Formula: C28H37NO9
- Molecular Weight:531.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC1806 | IC50 |
100 nM
Compound: 31; IHT
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Anticancer activity against human HCC1806 cells assessed as cell growth inhibition incubated for 24 hrs by MTS assay
Anticancer activity against human HCC1806 cells assessed as cell growth inhibition incubated for 24 hrs by MTS assay
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[PMID: 33650861] |
| HCC1937 | IC50 |
500 nM
Compound: 31; IHT
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Anticancer activity against human HCC1937 cells assessed as cell growth inhibition incubated for 24 hrs by MTS assay
Anticancer activity against human HCC1937 cells assessed as cell growth inhibition incubated for 24 hrs by MTS assay
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[PMID: 33650861] |
Chemical Information
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CAS No. 26833-86-3
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Molecular Weight 531.59
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Formula C28H37NO9
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SMILES
COC([C@@H](O)[C@@](CCC(C)C)(O)C(O[C@H]1[C@]2([H])[C@]3(C=C1OC)N(CCC3)CCC4=CC(OCO5)=C5C=C42)=O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lee JH, et al. Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway. Biomolecules. 2020 Nov 6;10(11):1521. [Content Brief]
[2]. Chen W, et al. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Biomed Pharmacother. 2018 Jul;103:435-442. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isoharringtonine Related Classifications
HY-N9954 Related Classifications
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