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Cat. No.: HY-N8052

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(-)-Antofine

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(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound.

For research use only. We do not sell to patients.

Purity: 99.40%
CAS No.: 32671-82-2
Formula: C₂₃H₂₅NO₃
Molecular Weight:363.45

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(-)-Antofine Chemical Structure

CAS No.: 32671-82-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.01 μM Compound: 5	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 22417638]
A549	GI₅₀	22 nM Compound: R-antofine	Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 21668000]
A549	IC₅₀	0.008 μM Compound: antofine	Cytotoxicity against human A549 cells by SRB microtiter plate assay Cytotoxicity against human A549 cells by SRB microtiter plate assay	[PMID: 17585747]
A549	IC₅₀	0.022 μM Compound: Antofine	Anticancer activity against human A549 cells after 72 hrs by SRB assay Anticancer activity against human A549 cells after 72 hrs by SRB assay	[PMID: 19645447]
A549	IC₅₀	0.022 μM Compound: antofine	Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis	[PMID: 22823514]
A549	IC₅₀	0.022 μM Compound: Antofine	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 28431881]
A549	IC₅₀	10 nM Compound: (-)-antofine A	Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay	[PMID: 25499434]
A549	IC₅₀	10.4 nM Compound: (-)-1	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 17049857]
A549	IC₅₀	11 nM Compound: 1, (-)-Antofine	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 23294831]
A549	IC₅₀	18 nM Compound: 1, (-)-Antofine	Cytotoxicity against human paclitaxel-resistant A549 cells after 72 hrs by SRB assay Cytotoxicity against human paclitaxel-resistant A549 cells after 72 hrs by SRB assay	[PMID: 23294831]
A549	IC₅₀	20 μM Compound: 23	Antiproliferative activity against human A549 cells Antiproliferative activity against human A549 cells	[PMID: 35033884]
A549	IC₅₀	8.52 nM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
CAKI-1	IC₅₀	6.23 nM Compound: 1	Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
CCRF-CEM	GI₅₀	5.2 nM Compound: (-)-antofine	Growth inhibition of human CEM cells Growth inhibition of human CEM cells	[PMID: 18077159]
DU-145	GI₅₀	25 nM Compound: R-antofine	Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay	[PMID: 21668000]
DU-145	IC₅₀	0.009 μM Compound: antofine	Cytotoxicity against human DU145 cells by SRB microtiter plate assay Cytotoxicity against human DU145 cells by SRB microtiter plate assay	[PMID: 17585747]
DU-145	IC₅₀	0.025 μM Compound: Antofine	Anticancer activity against human DU145 cells after 72 hrs by SRB assay Anticancer activity against human DU145 cells after 72 hrs by SRB assay	[PMID: 19645447]
DU-145	IC₅₀	0.025 μM Compound: antofine	Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis	[PMID: 22823514]
DU-145	IC₅₀	0.025 μM Compound: Antofine	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 28431881]
HCT-116	IC₅₀	6.03 nM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
HCT-116	IC₅₀	8 nM Compound: 1, (-)-Antofine	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 23294831]
HCT-116	IC₅₀	9.9 nM Compound: (-)-1	Cytotoxicity against human HCT116 cells by SRB assay Cytotoxicity against human HCT116 cells by SRB assay	[PMID: 17049857]
HCT-15	IC₅₀	13 nM Compound: 1, (-)-Antofine	Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay	[PMID: 23294831]
HL-60	GI₅₀	<0.001 μM Compound: 5	Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay	[PMID: 22417638]
HT-1080	IC₅₀	9.6 nM Compound: (-)-1	Cytotoxicity against human HT1080 cells by SRB assay Cytotoxicity against human HT1080 cells by SRB assay	[PMID: 17049857]
KB	GI₅₀	36 nM Compound: R-antofine	Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 21668000]
KB	IC₅₀	0.013 μM Compound: antofine	Cytotoxicity against human KB cells by SRB microtiter plate assay Cytotoxicity against human KB cells by SRB microtiter plate assay	[PMID: 17585747]
KB	IC₅₀	0.036 μM Compound: Antofine	Anticancer activity against human KB cells after 72 hrs by SRB assay Anticancer activity against human KB cells after 72 hrs by SRB assay	[PMID: 19645447]
KB	IC₅₀	0.036 μM Compound: antofine	Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis	[PMID: 22823514]
KB 3-1	IC₅₀	16 nM Compound: 1, (-)-(R)-13aalpha-antofine	Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay	[PMID: 12350151]
KB-V1	IC₅₀	14 nM Compound: 1, (-)-(R)-13aalpha-antofine	Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay	[PMID: 12350151]
MDA-MB-231	IC₅₀	0.012 μM Compound: Antofine	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28431881]
MDA-MB-231	IC₅₀	6.04 nM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
PANC-1	GI₅₀	2.2 nM Compound: (-)-antofine	Growth inhibition of human PANC1 cells Growth inhibition of human PANC1 cells	[PMID: 18077159]
PC-3	IC₅₀	12.34 nM Compound: 1	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
SK-HEP1	IC₅₀	6.32 nM Compound: 1	Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
SK-HEP1	IC₅₀	8 nM Compound: 1, (-)-Antofine	Cytotoxicity against human SKHEP1 cells after 72 hrs by SRB assay Cytotoxicity against human SKHEP1 cells after 72 hrs by SRB assay	[PMID: 23294831]
SNU-638	IC₅₀	10 nM Compound: 1, (-)-Antofine	Cytotoxicity against human SNU638 cells after 72 hrs by SRB assay Cytotoxicity against human SNU638 cells after 72 hrs by SRB assay	[PMID: 23294831]
SNU-638	IC₅₀	10.38 nM Compound: 1	Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
ZR-75-1	IC₅₀	0.008 μM Compound: antofine	Cytotoxicity against human ZR751cells by SRB microtiter plate assay Cytotoxicity against human ZR751cells by SRB microtiter plate assay	[PMID: 17585747]

Chemical Information

CAS No. 32671-82-2
Appearance Solid
Molecular Weight 363.45
Formula C₂₃H₂₅NO₃
Color White to off-white
SMILES

COC1=CC=C2C(C3=CC(OC)=C(OC)C=C3C4=C2CN5[C@@](CCC5)([H])C4)=C1
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xin Z, et al. Isolation of antofine from Cynanchum atratum BUNGE (Asclepiadaceae) and its antifungal activity against Penicillium digitatum[J]. Postharvest Biology and Technology, 2019, 157: 110961.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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