Karelinine
Karelinine is a steroidal alkaloid found in the bulbs of Fritillaria ussuriensis Maxim and Fritillaria karelinii. Karelinine shows accelerated absorption and elimination rates, and increased area under the curve (AUC0-t) when administered as part of the nanodispersion preparation (FUN) in rat plasma following oral administration.
For research use only. We do not sell to patients.
- Formula: C27H41NO5
- Molecular Weight:459.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 459.62
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Formula C27H41NO5
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SMILES
C[C@H](CN1)C[C@@]([C@]1([H])[C@H]2C)([H])OC32C[C@H](O)[C@@]4([H])[C@]5([H])CC(C6C[C@H](O)[C@@H](O)C[C@]6(C)[C@@]5([H])CC4=C3C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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How to Select the Route of Administration for Mammals
Route-of-administration selection in mammals is a pharmacokinetic, pharmacodynamic, formulation, animal-welfare, and translational decision, not a default technical choice. The selected route should match the study goal: intravenous dosing is most useful when complete systemic exposure and rapid onset are required, oral dosing is most translational for orally intended medicines but is affected by absorption and first-pass metabolism, subcutaneous or intramuscular dosing can provide slower systemic exposure, and intraperitoneal dosing can be useful in rodent proof-of-concept studies but may have limited clinical translation. Published route-comparison studies show that the same compound can produce different exposure, onset, bioavailability, tissue distribution, and tolerability depending on route; therefore, route choice should be supported by pilot pharmacokinetic or pharmacodynamic evidence when the literature is insufficient. Unresolved questions include how to standardize route sel
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Karelinine Related Classifications
HY-N18296 Related Classifications
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