Polyadenylic acid potassium
Based on 1 Customer Validation
Polyadenylic acid potassium (Poly(A)) is a polyribonucleotide. Polyadenylic acid potassium constitutes the 3'-poly(A) tail of eukaryotic mRNAs, governing mRNA maturation, stability, and translation initiation. Polyadenylic acid potassium serves as a target for studying nucleic acid structure-function relationships, with small molecules binding its tail influencing mRNA function and protein production. Polyadenylic acid (potassium) can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 90.00%
- CAS No.: 26763-19-9
- Molecular Weight:267KDa (Approximately)
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Polyadenylic acid potassium 55 μM undergoes pH-dependent conformational transitions, existing as a single-stranded helix at physiological pH, an intermediate B-form near pH 5.81, a double-stranded A-form at pH 4.0, and an aggregated "frozen" form at pH <3.8[1].
Polyadenylic acid potassium undergoes stacking and hydrogen bonding interactions with Lauroyl Uridine-containing liposomes to induce ordered base orientation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 26763-19-9
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Appearance Solid
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Molecular Weight 267KDa (Approximately)
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Color White to off-white
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SMILES
NC1=C2C(N([C@@H]3O[C@H](COP(O)(O[K])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[n]
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Synonyms
Poly(A)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Giri P, et al. Molecular aspects of small molecules-poly(A) interaction: an approach to RNA based drug design. Curr Med Chem. 2009;16(8):965-987. [Content Brief]
[2]. Cuomo F, et al. Polyadenylic acid binding on cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine. Colloids Surf B Biointerfaces. 2011;82(2):277-282. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polyadenylic acid potassium Related Classifications
HY-W416291 Related Classifications
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