Methylliberine
Based on 1 Customer Validation
Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy.
For research use only. We do not sell to patients.
- Purity : 99.94%
- CAS No.: 51168-26-4
- Formula: C9H12N4O3
- Molecular Weight:224.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
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Biological Activity
Description
In Vitro
Methylliberine (5-5000 µg/plate) is nonmutagenic in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2 uvrA with and without S9 metabolic activation[5].
Methylliberine (125-2000 µg/mL; 3-28 h) is non-clastogenic in V79 male Chinese hamster lung cells under short-term exposure up to 2000 µg/mL and long-term exposure up to 500 µg/mL, with and without S9 metabolic activation[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 51168-26-4
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Appearance Solid
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Molecular Weight 224.22
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Formula C9H12N4O3
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Color White to off-white
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SMILES
O=C1C2=C(N(C)C(N2C)=O)N=C(N1C)OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 1 mg/mL (4.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tartar JL, et al. A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers. Cureus. 2021 Dec;13(12):e20534. [Content Brief]
[5]. Murbach TS, et al. A Toxicological Evaluation of Methylliberine (Dynamine®). Journal of toxicology. 2019;2019:4981420. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4599 mL | 22.2995 mL | 44.5991 mL | 111.4976 mL |
Methylliberine Related Classifications
HY-N7564 Related Classifications
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Keywords
- Methylliberine
- 51168-26-4
- Adenosine Receptor
- 1,3,7-trimethylxanthine catabolism
- C-8 oxidation pathway
- S9 metabolic activation
- adenosine A1 receptor
- adenosine receptors
- bacterial reverse mutation test
- bone marrow micronucleus test
- mammalian chromosomal aberration test
- spermatogenesis
- testicular atrophy
- Inhibitor
- inhibitor
- inhibit