51168-26-4
51168-26-4
Chemical Structure
Methylliberine
- CAS No.: 51168-26-4
- Formula:C9H12N4O3
- Molecular Weight:224.22
IUPAC Name: 2-methoxy-1,7,9-trimethyl-7,9-dihydro-1H-purine-6,8-dione
InChIKey: ZVQXCXPGLSBNCX-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N2C)=O)N=C(N1C)OC
Biological Activity: Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methylliberine | 99.94% | Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy. | ||||||||||||||||||||
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Methylliberine (Standard) | ≥98% | Methylliberine (Standard) is the analytical standard of Methylliberine (HY-N7564). This product is intended for research and analytical applications. Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy. | ||||||||||||||||||||
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Ambuphylline | Ambuphylline (Bufylline) is a bronchodilator. Ambuphylline is a theophylline derivative possibly acting through phosphodiesterase inhibition. Ambuphylline can be used for the research of asthma and other lung diseases. | |||||||||||||||||||||
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Cafaminol | Cafaminol (Methylcoffanolamine) is a vasoconstrictor and anticatarrhal that selectively binds to alpha-1 receptors, causing blood vessels to constrict. Cafaminol is an xanthine derivative which can be utilized in decongestant and antitumor research. | |||||||||||||||||||||
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Etamiphyllin | 99.33% | Etamiphyllin (Etamiphylline) is a respiratory and cardiac stimulant. Etamiphyllin camsylate relaxes bronchial and bronchiolar smooth muscle to open airways, and increases cardiac output without elevating heart rate. The level of Etamiphyllin camsylate decreases in mice with ulcerative colitis, and it is positively correlated with *Bifidobacterium* and *Faecalibacterium*. Etamiphyllin camsylate can be applied to research related to chronic obstructive pulmonary disease, respiratory failure and ulcerative colitis. | ||||||||||||||||||||
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Tetramethyluric acid | 99.63% | Tetramethyluric acid (1,3,7,9-Tetramethyluric acid) is an orally active purine alkaloid in Coffea species and Camellia kucha. Tetramethyluric acid exhibits antiviral, and anti-inflammatory activity. Tetramethyluric acid can be used for the research of inflammation disease, and influenza virus infection. | ||||||||||||||||||||
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Isbufylline | Isbufylline is a Phosphodiesterase inhibitor. Isbufylline is orally available. Isbufylline can be used in the research of respiratory diseases and inflammation such as asthma and pneumonia. | |||||||||||||||||||||
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Cofpropamine | Cofpropamine, a caffeine derivative that inhibits polyadenylation, enhances the inhibitory effect of cyclophosphamide (HY-17420) in rat adjuvant arthritis and mouse collagen arthritis models. | |||||||||||||||||||||
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Etofylline | 99.72% | Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos. | ||||||||||||||||||||
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Acefylline (Standard) | ≥98% | Acefylline (Theophyllineacetic acid) (Standard) is the analytical standard of Acefylline (HY-B1505). This product is intended for research and analytical applications. Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research. | ||||||||||||||||||||
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Proxyphylline | 99.93% | Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator. | ||||||||||||||||||||
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DMPX | 99.66% | DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A2A adenosine receptor (A2A AR) antagonist that crosses the blood-brain barrier, with a Ki of 11 μM for rat A2 adenosine receptor and a Ki of 45 μM for rat A1 adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease. | ||||||||||||||||||||
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References
- [1]. Tartar JL, et al. A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers. Cureus. 2021 Dec;13(12):e20534. [Content Brief]
- [2]. Subuyuj Hernandez GA. Characterization of Caffeine Biodegradation and Transcriptional Regulation in Methylorubrum populi PINKEL [master's thesis]. Davis (CA): University of California, Davis; 2023.
- [3]. Bloomer RJ, et al. Acute impact of a single dose of Dynamine®, TeaCrine®, caffeine, and their combination on systemic hemodynamics and associated measures in men and women. Med Res Arch. 2020;8(4).
- [4]. La Monica MB, et al. Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women. Nutrients. 2023 Oct 24;15(21):4509.
- [5]. Murbach TS, et al. A Toxicological Evaluation of Methylliberine (Dynamine®). Journal of toxicology. 2019;2019:4981420. [Content Brief]
