Cycloposine
Based on 1 Customer Validation
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound that may induce cyclopia in pregnant Mianyang embryos.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 23185-94-6
- Formula: C33H51NO7
- Molecular Weight:573.76
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Cycloposine producs fetal cyclopia and related central nervous system malformations in sheep[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 23185-94-6
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Appearance Solid
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Molecular Weight 573.76
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Formula C33H51NO7
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Color White to off-white
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SMILES
CC1=C(C[C@@]2([H])[C@@]3([H])CC=C4[C@@]2(CC[C@@H](C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)[C@@]3([H])CC[C@]16O[C@@]7([H])[C@](NC[C@H](C7)C)([H])[C@H]6C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 46.67 mg/mL (81.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (643 KB)
- English - EN (643 KB)
- Français - FR (643 KB)
- Deutsch - DE (643 KB)
- Norwegian - NO (643 KB)
- Español - ES (643 KB)
- Swedish - SV (643 KB)
- Italian - IT (643 KB)
- Korean - KR (643 KB)
- Portuguese - PT (643 KB)
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Handling Instructions (2659 KB)
References
[1]. Chandler CM, et, al. Improved extraction and complete mass spectral characterization of steroidal alkaloids from Veratrum californicum. Nat Prod Commun. 2013 Aug;8(8):1059-64. [Content Brief]
[2]. Keeler RF. Teratogenic compounds of Veratrum californicum (Durand). VII. The structure of the glycosidic alkaloid cycloposine. Steroids. 1969 May;13(5):579-88. [Content Brief]
[3]. Heretsch P, et al. Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives. Angew Chem Int Ed Engl. 2010 May 3;49(20):3418-27. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7429 mL | 8.7144 mL | 17.4289 mL | 43.5722 mL |
| 5 mM | 0.3486 mL | 1.7429 mL | 3.4858 mL | 8.7144 mL | |
| 10 mM | 0.1743 mL | 0.8714 mL | 1.7429 mL | 4.3572 mL | |
| 15 mM | 0.1162 mL | 0.5810 mL | 1.1619 mL | 2.9048 mL | |
| 20 mM | 0.0871 mL | 0.4357 mL | 0.8714 mL | 2.1786 mL | |
| 25 mM | 0.0697 mL | 0.3486 mL | 0.6972 mL | 1.7429 mL | |
| 30 mM | 0.0581 mL | 0.2905 mL | 0.5810 mL | 1.4524 mL | |
| 40 mM | 0.0436 mL | 0.2179 mL | 0.4357 mL | 1.0893 mL | |
| 50 mM | 0.0349 mL | 0.1743 mL | 0.3486 mL | 0.8714 mL | |
| 60 mM | 0.0290 mL | 0.1452 mL | 0.2905 mL | 0.7262 mL | |
| 80 mM | 0.0218 mL | 0.1089 mL | 0.2179 mL | 0.5447 mL |
Cycloposine Related Classifications
HY-128683 Related Classifications
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