Chingchengenamide A
Based on 1 Customer Validation
Chingchengenamide A is a natural alkaloid.
For research use only. We do not sell to patients.
- Purity: 96%
- CAS No.: 139906-29-9
- Formula: C18H23NO3
- Molecular Weight:301.38
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
40 μM
Compound: 13
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Antiproliferative activity against human A549 cells after 3 days by SRB assay
Antiproliferative activity against human A549 cells after 3 days by SRB assay
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[PMID: 25241925] |
Chingchengenamide A (100 μg; 24 h) exhibits antimicrobial activity against tested gram-positive and gram-negative bacteria, with the highest zone of inhibition (21 mm) against Pseudomonas aeruginosa[1].
Chingchengenamide A exhibits favorable ADMET properties including high human intestinal absorption, good Caco-2 permeability, and non-carcinogenicity[1].
Chingchengenamide A (0.1-100 μM; 90 min) increases glucose uptake but does not affect fatty acid uptake in differentiated Caco-2 cells[2].
Chingchengenamide A (0.00125-0.01 mg/mL; 48 h) potently kills Aedes albopictus third instar larvae[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chingchengenamide A (10-20 mg/kg; p.o.) exhibits dose-dependent analgesic activity in Swiss albino mice (Acetic acid (HY-Y0319)-induced writhing)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice induced by Castor oil (4–5 weeks old, both genders)[1]
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Dosage:10 mg/kg; 20 mg/kg
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Administration:p.o.
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Result:Reduced diarrhea by 33.33% at 10 mg/kg; reduced diarrhea by 40% at 20 mg/kg.
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Animal Model:Swiss albino mice induced by Acetic acid (4–5 weeks old, both genders)[1]
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Dosage:10 mg/kg; 20 mg/kg
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Administration:p.o.
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Result:Reduced writhing by 34.69% at 10 mg/kg; reduced writhing by 42.86% at 20 mg/kg.
Chemical Information
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CAS No. 139906-29-9
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Appearance Solid
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Molecular Weight 301.38
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Formula C18H23NO3
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Color White to off-white
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SMILES
CC(C)CNC(/C=C/C=C/CCC1=CC=C(OCO2)C2=C1)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Shandhi SP, et al. Isolation, Structure Elucidation, and Bioactivity Evaluation of Two Alkaloids From Piper chaba H. Stem: A Traditional Medicinal Spice and Its Chemico-Pharmacological Aspects. Food Sci Nutr. 2024;12(12):10680-10698. Published 2024 Nov 22. [Content Brief]
[2]. Obst K, et al. Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells. Phytochemistry. 2017;135:181-190. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chingchengenamide A Related Classifications
HY-N16926 Related Classifications
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