Chingchengenamide A

Name: Chingchengenamide A
Brand: MedChemExpress
SKU: HY-N16926
Rating: 4.5 (1 reviews)

Cat. No.: HY-N16926 Purity: 96%: Data Sheet
COA

SDS
Handling Instructions
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Chingchengenamide A is a natural alkaloid.

For research use only. We do not sell to patients.

Chingchengenamide A Chemical Structure

CAS No. : 139906-29-9

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1 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Chingchengenamide A is a natural alkaloid.

In Vitro

Chingchengenamide A (100 μg; 24 h) exhibits antimicrobial activity against tested gram-positive and gram-negative bacteria, with the highest zone of inhibition (21 mm) against Pseudomonas aeruginosa^[1].
Chingchengenamide A exhibits favorable ADMET properties including high human intestinal absorption, good Caco-2 permeability, and non-carcinogenicity^[1].
Chingchengenamide A (0.1-100 μM; 90 min) increases glucose uptake but does not affect fatty acid uptake in differentiated Caco-2 cells^[2].
Chingchengenamide A (0.00125-0.01 mg/mL; 48 h) potently kills Aedes albopictus third instar larvae^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chingchengenamide A (10-20 mg/kg; p.o.) exhibits dose-dependent antidiarrheal activity in Swiss albino mice (Castor oil (HY-107799)-induced diarrhea)^[1].
Chingchengenamide A (10-20 mg/kg; p.o.) exhibits dose-dependent analgesic activity in Swiss albino mice (Acetic acid (HY-Y0319)-induced writhing)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice induced by Castor oil (4–5 weeks old, both genders)^[1]
Dosage:	10 mg/kg; 20 mg/kg
Administration:	p.o.
Result:	Reduced diarrhea by 33.33% at 10 mg/kg; reduced diarrhea by 40% at 20 mg/kg.

Animal Model:	Swiss albino mice induced by Acetic acid (4–5 weeks old, both genders)^[1]
Dosage:	10 mg/kg; 20 mg/kg
Administration:	p.o.
Result:	Reduced writhing by 34.69% at 10 mg/kg; reduced writhing by 42.86% at 20 mg/kg.

Molecular Weight

301.38

Formula

C₁₈H₂₃NO₃

CAS No.

139906-29-9

Appearance

Solid

Color

White to off-white

SMILES

CC(C)CNC(/C=C/C=C/CCC1=CC=C(OCO2)C2=C1)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 96%

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Data Sheet (268 KB) SDS (252 KB)

COA (242 KB)

Handling Instructions (2659 KB)

References

[1]. Shandhi SP, et al. Isolation, Structure Elucidation, and Bioactivity Evaluation of Two Alkaloids From Piper chaba H. Stem: A Traditional Medicinal Spice and Its Chemico-Pharmacological Aspects. Food Sci Nutr. 2024;12(12):10680-10698. Published 2024 Nov 22. [Content Brief]

[2]. Obst K, et al. Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells. Phytochemistry. 2017;135:181-190. [Content Brief]

[3]. Seo S M, et al. Larvicidal activities of Piper kadsura (Choisy) Ohwi extract and its constituents against Aedes albopictus, toxicity to non-target organisms and development of cellulose nanocrystal-stabilized Pickering emulsion[J]. Industrial Crops and Products, 2021, 162: 113270.