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Cat. No.: HY-102010

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Pancratistatin

(Synonyms: (+)-Pancratistatin)

Pancratistatin is an isoquinoline alkaloid that can be isolated from Hymenocallis littoralis. Pancratistatin induces apoptosis of human melanoma cells. Pancratistatin can be used for the research of neuroblastoma, leukemia and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 96203-70-2
Formula: C₁₄H₁₅NO₈
Molecular Weight:325.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Pancratistatin Chemical Structure

CAS No.: 96203-70-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	ED₅₀	0.02 μg/mL Compound: 1	Growth inhibition of human BXPC3 cells after 48 hrs Growth inhibition of human BXPC3 cells after 48 hrs	[PMID: 17346078]
BXPC-3	ED₅₀	0.043 μg/mL Compound: 1	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 16124772]
BXPC-3	GI₅₀	0.02 μg/mL Compound: 1a	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 22413911]
BXPC-3	GI₅₀	0.02 μg/mL Compound: 1a	Cytotoxicity against human BxPC3 cells Cytotoxicity against human BxPC3 cells	[PMID: 15043403]
DU-145	ED₅₀	0.037 μg/mL Compound: 1	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 16124772]
DU-145	GI₅₀	0.015 μg/mL Compound: 1	Growth inhibition of human DU145 cells after 48 hrs Growth inhibition of human DU145 cells after 48 hrs	[PMID: 17346078]
DU-145	GI₅₀	0.015 μg/mL Compound: 1a	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 22413911]
DU-145	GI₅₀	0.015 μg/mL Compound: 1a	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 15043403]
DU-145	GI₅₀	0.016 μg/mL Compound: 1	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 16441059]
KM-20L2	ED₅₀	0.048 μg/mL Compound: 1	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 16124772]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1	Growth inhibition of human KM20L2 cells after 48 hrs Growth inhibition of human KM20L2 cells after 48 hrs	[PMID: 17346078]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1a	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 22413911]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1a	Cytotoxicity against human KM20L2 cells Cytotoxicity against human KM20L2 cells	[PMID: 15043403]
KM-20L2	GI₅₀	0.026 μg/mL Compound: 1	Growth inhibition of human KM20L2 cells Growth inhibition of human KM20L2 cells	[PMID: 16441059]
MCF7	ED₅₀	0.023 μg/mL Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs Growth inhibition of human MCF7 cells after 48 hrs	[PMID: 17346078]
MCF7	ED₅₀	0.035 μg/mL Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 16124772]
MCF7	GI₅₀	0.023 μg/mL Compound: 1a	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 22413911]
MCF7	GI₅₀	0.023 μg/mL Compound: 1a	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15043403]
MCF7	GI₅₀	0.032 μg/mL Compound: 1	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 16441059]
MCF7	IC₅₀	0.071 μM Compound: 5	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 22921081]
NCI-H460	ED₅₀	0.029 μg/mL Compound: 1	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 16124772]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs Growth inhibition of human NCI-H460 cells after 48 hrs	[PMID: 17346078]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1a	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 22413911]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1a	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 15043403]
NCI-H460	GI₅₀	0.048 μg/mL Compound: 1	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 16441059]
P388	ED₅₀	<0.01 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 6549467]
P388	ED₅₀	0.01 μg/mL Compound: 1	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 8277308]
P388	ED₅₀	0.017 μg/mL Compound: 1	Growth inhibition of murine P388 cells after 48 hrs Growth inhibition of murine P388 cells after 48 hrs	[PMID: 17346078]
P388	ED₅₀	0.017 μg/mL Compound: 1a	Cytotoxicity against mouse P388 cells after 48 hrs by cell counting Cytotoxicity against mouse P388 cells after 48 hrs by cell counting	[PMID: 22413911]
P388	ED₅₀	0.017 μg/mL Compound: 1a	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 15043403]
P388	ED₅₀	0.039 μg/mL Compound: 1	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 16441059]
P388	ED₅₀	0.039 μg/mL Compound: 1, PST	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18225861]
P388	ED₅₀	0.048 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 16124772]
SF-268	ED₅₀	0.032 μg/mL Compound: 1	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 16124772]
SF-268	GI₅₀	0.014 μg/mL Compound: 1	Growth inhibition of human SF268 cells after 48 hrs Growth inhibition of human SF268 cells after 48 hrs	[PMID: 17346078]
SF-268	GI₅₀	0.014 μg/mL Compound: 1a	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 22413911]
SF-268	GI₅₀	0.014 μg/mL Compound: 1a	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 15043403]
Vero	IC₅₀	0.016 μg/mL Compound: 4	Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.022 μg/mL Compound: 4	Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.063 μg/mL Compound: 4	Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
Vero	IC₅₀	0.16 μg/mL Compound: 4	Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]

Chemical Information

CAS No. 96203-70-2
Molecular Weight 325.27
Formula C₁₄H₁₅NO₈
SMILES

O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@]2([H])C3=C1C(O)=C4C(OCO4)=C3
Synonyms

(+)-Pancratistatin
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chatterjee SJ, et al. Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. Melanoma Res. 2011 Feb;21(1):1-11. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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