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Cat. No.: HY-W268334

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1,2,3,4-Tetrahydronorharman-1-one

Name: 1,2,3,4-Tetrahydronorharman-1-one
Brand: MedChemExpress
SKU: HY-W268334
Price: 366.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge.

For research use only. We do not sell to patients.

CAS No.: 17952-82-8
Formula: C₁₁H₁₀N₂O
Molecular Weight:186.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

1,2,3,4-Tetrahydronorharman-1-one Chemical Structure

CAS No.: 17952-82-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge^[1].

All Parasite Isoforms :

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>40 μM Compound: 14	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22342628]
A549	IC₅₀	10.11 μg/mL Compound: 79	Cytotoxicity against human A549 cells incubated for 48 hrs by neutral red dye based assay Cytotoxicity against human A549 cells incubated for 48 hrs by neutral red dye based assay	[PMID: 34332400]
HCT-116	IC₅₀	7.45 μg/mL Compound: 79	Cytotoxicity against human HCT-116 cells incubated for 48 hrs by neutral red dye based assay Cytotoxicity against human HCT-116 cells incubated for 48 hrs by neutral red dye based assay	[PMID: 34332400]
HL-60	IC₅₀	>40 μM Compound: 14	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 22342628]
MCF7	IC₅₀	>40 μM Compound: 14	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22342628]
MCF7	IC₅₀	8.27 μg/mL Compound: 79	Cytotoxicity against human MCF7 cells incubated for 48 hrs by neutral red dye based assay Cytotoxicity against human MCF7 cells incubated for 48 hrs by neutral red dye based assay	[PMID: 34332400]
SMMC-7721	IC₅₀	>40 μM Compound: 14	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 22342628]
SW480	IC₅₀	>40 μM Compound: 14	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 22342628]

Chemical Information

CAS No. 17952-82-8
Molecular Weight 186.21
Formula C₁₁H₁₀N₂O
SMILES

O=C1NCCC2=C1NC3=CC=CC=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Karumanchi V Rao, et al. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. J Nat Prod. 2003 Jun;66(6):823-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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1,2,3,4-Tetrahydronorharman-1-one

All Parasite Isoforms

All Antibiotic Isoforms