β-Carboline alkaloids from the leaves of Trigonostemon lii Y.T. Chang

  • Bioorg Med Chem Lett. 2012 Mar 15;22(6):2296-9. doi: 10.1016/j.bmcl.2012.01.106.
Shi-Fei Li  1 ,  Yu Zhang ,  Yan Li ,  Xin-Rao Li ,  Ling-Mei Kong ,  Cheng-Jian Tan ,  Shun-Lin Li ,  Ying-Tong Di ,  Hong-Ping He ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
PMID: 22342628 DOI: 10.1016/j.bmcl.2012.01.106
Abstract

A phytochemical work on the alkaloid constituents from Trigonostemon lii Y.T. Chang was conducted to give six new β-carboline Alkaloids, trigonostemines A-F (1-6) and eight known β-carboline Alkaloids (7-14). Their structures were elucidated by extensive spectroscopic techniques including 2D NMR experiments and mass spectrometry. All of the compounds were evaluated for their cytotoxic activities against the HL-60, SMMC-7721, A-549, MCF-7, and SW480 human Cancer cell lines. Trigonostemines A and B (1 and 2) exhibited stronger inhibitory activities than the positive control (cisplatin) in some cell lines.