Salsolidine hydrochloride
Based on 2 publication(s) in Google Scholar
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 63283-42-1
- Formula: C12H18ClNO2
- Molecular Weight:243.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Salsolidine hydrochloride
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Biological Activity
MAO A[1]
Salsolidine hydrochloride is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki=6 μM and 186 μM)[1].
Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2].
Salsolidine has the potential of inhibiting acetylcholinestearse and butyrylcholinesterase[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 63283-42-1
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Molecular Weight 243.73
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Formula C12H18ClNO2
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SMILES
CC1NCCC2=C1C=C(OC)C(OC)=C2.Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Purity & Documentation
References
[1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [Content Brief]
[2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [Content Brief]
[3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Salsolidine hydrochloride Related Classifications
HY-22385A Related Classifications
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