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  3. Corynoxine hydrochloride

Corynoxine hydrochloride 

Cat. No.: HY-N0901B
Handling Instructions

Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway.

For research use only. We do not sell to patients.

Corynoxine hydrochloride Chemical Structure

Corynoxine hydrochloride Chemical Structure

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Description

Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway[1].

In Vitro

Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner[1].
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: N2a and SH-SY5Y cells
Concentration: 6.25, 12.5, 25 μM
Incubation Time: 6, 12 hours
Result: Induced autophagy in neuronal cell lines.
In Vivo

Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice[2].
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

420.93

Formula

C₂₂H₂₉ClN₂O₄

SMILES

[H]Cl.O=C(NC1=C2C=CC=C1)[[email protected]@]32[[email protected]@](C[[email protected]](/C(C(OC)=O)=C\OC)[[email protected]](CC)C4)([H])N4CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CorynoxineAutophagytetracyclicoxindolealkaloidUncariamacrophyllaautophagysynuclein AktmTORInhibitorinhibitorinhibit

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Product Name:
Corynoxine hydrochloride
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HY-N0901B
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