Corynoxine hydrochloride
Based on 4 publication(s) in Google Scholar
Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway.
For research use only. We do not sell to patients.
- Formula: C22H29ClN2O4
- Molecular Weight:420.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Corynoxine hydrochloride
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Biological Activity
Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner[1].
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N2a and SH-SY5Y cells
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Concentration:6.25, 12.5, 25 μM
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Incubation Time:6, 12 hours
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Result:Induced autophagy in neuronal cell lines.
Chemical Information
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Molecular Weight 420.93
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Formula C22H29ClN2O4
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SMILES
[H]Cl.O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Toxicol Appl Pharmacol
Corynoxine suppresses hepatocellular carcinoma progression by forming the ROS-STAT3 cycle. [Abstract]2026 Jun 16:514:117917. PMID: 42303055 -
Transl Vis Sci Technol
Pathogenicity and Functional Analysis of Multi-Variant Allele of RPE65 Causing Retinitis Pigmentosa. [Abstract]2026 Feb 2;15(2):1. PMID: 41626883 -
Hereditas
Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expression. [Abstract]2024 Nov 7;161(1):41. PMID: 39511658 -
Plant Biotechnol (Tokyo)
A sterile plant culture system of Uncaria rhynchophylla as a biosynthetic model of monoterpenoid indole alkaloids. [Abstract]2025 Jun 25;42(2):145-154. PMID: 40636431
Purity & Documentation
References
[1]. Chen LL, et, al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7. [Content Brief]
[2]. Sakakibara I, et, al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Corynoxine hydrochloride Related Classifications
HY-N0901B Related Classifications
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