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  3. Mahanine

Mahanine 

Cat. No.: HY-121368
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Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection treatment research.

For research use only. We do not sell to patients.

Mahanine Chemical Structure

Mahanine Chemical Structure

CAS No. : 28360-49-8

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Description

Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection treatment research[1].

In Vitro

Mahanine (0-50 µM; 24 or 48 hours) induces a dose-dependent decrease in cell viability of AG83 promastigotes after 24 hr and 48 hr; the IC50 values were 16.7±1.7 µM and 11.5±0.8 µM respectively. In a drug resistant GE1 strain, Mahanine treatment exhibits dose-dependent cell death in 24 and 48 hr treatment with IC50 values 40.3±2.2 µM and 29.1±1.3 µM respectively[1].
Mahanine (5.0 and 10 µM; 24 hours) exhibits increased accumulation of cells at G2/M phase being 39.0±1.90% and 41.0±2.10% respectively compared to untreated promastigotes (35.3 ± 2.60%) in AG83 promastigote [1].
Mahanine (25 µM; 24 hours) exhibitssignificantly increased intracellular ROS level within 20 min (MFI being 889 ± 26) which reached to 1288 ± 56 after one hour compared to the basal level (604 ± 34) in untreated promastigote. H2DCFDA positivity was measured by FACS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, and leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmania infection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice with virulent AG83 promastigotes[1]
Dosage: 20 mg/kg-40 mg/kg
Administration: oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days
Result: Had the potential to clear parasite burden in vivo.
Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T cell proliferation in vivo.
Molecular Weight

347.45

Formula

C₂₃H₂₅NO₂

CAS No.
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Mahanine
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