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Art. -Nr.: HY-117190

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Pseudolycorine

Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity.

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CAS. Nr.: 29429-03-6
Formel: C₁₆H₁₉NO₄
Molecular Weight:289.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Pseudolycorine Chemical Structure

CAS. Nr.: 29429-03-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.4 μM Compound: 3	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
A549	IC₅₀	7.5 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay	[PMID: 19788245]
B16-F10	IC₅₀	7.5 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 19788245]
B16-F10	IC₅₀	7.5 μM Compound: 3	Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
Hs 683	IC₅₀	7.9 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay	[PMID: 19788245]
Hs 683	IC₅₀	7.9 μM Compound: 3	Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
NHDF	IC₅₀	66.9 μM Compound: 18, pseudolycorine	Growth inhibition of human NHDF after 72 hrs by MTT assay Growth inhibition of human NHDF after 72 hrs by MTT assay	[PMID: 19788245]
SK-MEL	IC₅₀	>10 μM Compound: 3	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
SK-MEL-28	IC₅₀	>10 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 19788245]
U-373MG ATCC	IC₅₀	7.8 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay	[PMID: 19788245]
U-373MG ATCC	IC₅₀	7.8 μM Compound: 3	Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
Vero	IC₅₀	0.28 μg/mL Compound: 17	Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.35 μg/mL Compound: 17	Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.39 μg/mL Compound: 17	Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
Vero	IC₅₀	0.6 μg/mL Compound: 17	Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.63 μg/mL Compound: 17	Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
WI-38	IC₅₀	44 μM Compound: 18, pseudolycorine	Growth inhibition of human WI38 cells after 72 hrs by MTT assay Growth inhibition of human WI38 cells after 72 hrs by MTT assay	[PMID: 19788245]

In Vitro

Pseudolycorine shows growth-inhibitory activity, with IC₅₀ values of 7.4 μM, 7.9 μM, 7.9 μM, 7.8 μM, and 7.5 μM for A549, OE21, Hs683, U373, and B16F10 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 29429-03-6
Molecular Weight 289.33
Formel C₁₆H₁₉NO₄
SMILES

O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(O)C(OC)=C4
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gwendoline Van Goietsenoven, et al. Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. J Nat Prod. 2010 Jul 23;73(7):1223-7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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