1. Alkaloids
  2. Vasicinone

Vasicinone (Synonyms: (-)-Vasicinone)

Cat. No.: HY-N1100
Handling Instructions

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders.

For research use only. We do not sell to patients.

Vasicinone Chemical Structure

Vasicinone Chemical Structure

CAS No. : 486-64-6

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Description

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].

In Vitro

Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1].
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1].
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 1~30 µM
Incubation Time: 24 hours
Result: Significantly reversed the paraquat-induced reduction in cell viability.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 10 and 15 µM
Incubation Time: 24 hours
Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway.

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 10 and 15 µM
Incubation Time: 24 hours
Result: Dose-dependently reduced the percentage of apoptotic cells.
Molecular Weight

202.21

Formula

C₁₁H₁₀N₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Vasicinone
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HY-N1100
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