Geissoschizine methyl ether

Cat. No.: HY-N2411 Purity: 99.63%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT_1A receptor agonist.

For research use only. We do not sell to patients.

Geissoschizine methyl ether Chemical Structure

CAS No. : 60314-89-8

Size	Price	Stock	Quantity
1 mg	USD 171	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 514	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

5-HT_1A Receptor

Molecular Weight

366.45

Formula

C₂₂H₂₆N₂O₃

CAS No.

60314-89-8

Appearance

Solid

Color

White to off-white

SMILES

COC(/C([C@H]1C[C@@]2([H])C3=C(CCN2C/C1=C/C)C4=CC=CC=C4N3)=C\OC)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7289 mL	13.6444 mL	27.2889 mL
5 mM	0.5458 mL	2.7289 mL	5.4578 mL
10 mM	0.2729 mL	1.3644 mL	2.7289 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (256 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Matsumoto T, et al. In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan. Xenobiotica. 2016;46(4):325-34. [Content Brief]

[2]. Nishi A, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012 Apr 5;207:124-36. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7289 mL	13.6444 mL	27.2889 mL	68.2221 mL
	5 mM	0.5458 mL	2.7289 mL	5.4578 mL	13.6444 mL
	10 mM	0.2729 mL	1.3644 mL	2.7289 mL	6.8222 mL
	15 mM	0.1819 mL	0.9096 mL	1.8193 mL	4.5481 mL
	20 mM	0.1364 mL	0.6822 mL	1.3644 mL	3.4111 mL
	25 mM	0.1092 mL	0.5458 mL	1.0916 mL	2.7289 mL
	30 mM	0.0910 mL	0.4548 mL	0.9096 mL	2.2741 mL
	40 mM	0.0682 mL	0.3411 mL	0.6822 mL	1.7056 mL
	50 mM	0.0546 mL	0.2729 mL	0.5458 mL	1.3644 mL
	60 mM	0.0455 mL	0.2274 mL	0.4548 mL	1.1370 mL
	80 mM	0.0341 mL	0.1706 mL	0.3411 mL	0.8528 mL
	100 mM	0.0273 mL	0.1364 mL	0.2729 mL	0.6822 mL